949101-24-0Relevant academic research and scientific papers
Expeditious synthesis of indolizine derivatives via iodine mediated 5-endo-dig cyclization
Kim, Ikyon,Choi, Jihyun,Won, Hye Kyoung,Lee, Ge Hyeoung
, p. 6863 - 6867 (2007)
Iodine-mediated 5-endo-dig cyclization of propargylic esters 2 at room temperature proceeded smoothly to give highly functionalized indolizines 3 in excellent yields. A pyridine group was employed as a nucleophilic partner in this facile process for the f
Straightforward Access to 2-Iodoindolizines via Iodine-Mediated Cyclization of 2-Pyridylallenes
Alahyen, Ismail,Fensterbank, Louis,Lemière, Gilles,Martinez, Thibaut,Mouriès-Mansuy, Virginie
, p. 817 - 821 (2020/07/14)
A metal-free access to 2-iodo-1,3-disubstituted indolizines has been developed. The proposed synthesis is relatively simple and efficient and involves the iodine-triggered 5-endo-trig cyclization of 2-pyridylallene precursors. While it can be conducted on
Synthesis of Indolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation
Xu, Tongyu,Alper, Howard
supporting information, p. 4526 - 4529 (2015/09/28)
An efficient synthesis of indolizine derivatives by palladium-catalyzed oxidative carbonylation of propargylic pyridines has been developed. The reaction can be conducted at room temperature and under 3 bar of CO in the presence of Pd2(dba)sub
Multisubstituted N-fused heterocycles via transition metal-catalyzed cycloisomerization protocols
Seregin, Ilya V.,Schammel, Alex W.,Gevorgyan, Vladimir
, p. 6876 - 6883 (2008/09/21)
Two complementary protocols for assembly of multisubstituted N-fused heterocycles have been developed. It was demonstrated that 1,3-disubstituted N-fused heterocycles, including indolizines, pyrroloquinoxalines, and pyrrolothiazoles can easily be synthesized via an exceptionally mild and efficient method involving a novel silver-catalyzed cycloizomerization of propargyl-containing heterocycles. Alternatively, 1,2-disubstituted heterocycles can be accessed through the novel cascade transformation involving an alkyne-vinylidene isomerization with concomitant 1,2-shift of hydrogen, silyl, stannyl, or germyl groups. This mild and simple method allows for selective and highly efficient synthesis of indolizines, pyrroloisoquinolines, pyrroloquinoxalines, pyrrolopyrazines, and pyrrolothiazoles.
Base- and ligand-free room-temperature synthesis of N-fused heteroaromatic compounds via the transition metal-catalyzed cycloisomerization protocol
Seregin, Iiya V.,Schammel, Alex W.,Gevorgyan, Vladimir
, p. 3433 - 3436 (2008/02/12)
A new practical method for the synthesis of N-fused heterocycles via the transition metal-catalyzed cycloisomerization of heterocyles possessing a propagyl group has been developed. This very mild, base- and ligand-free method allows for the synthesis of diverse fused heterocyclic cores in good to excellent yields.
Highly efficient synthesis of functionalized indolizines and indolizinones by copper-catalyzed cycloisomerizations of propargylic pyridines
Yan, Bin,Zhou, Yebing,Zhang, Hao,Chen, Jingjin,Liu, Yuanhong
, p. 7783 - 7786 (2008/03/12)
(Chemical Equation Presented) The copper-catalyzed cycloisomerizations of 2-pyridyl-substituted propargylic acetates and its derivatives are described, which offer an efficient route to C-1 oxygenated indolizines with a wide range of substituents under mild reaction conditions. The presented method could be readily applied to the synthesis of indolizinones through a cyclization/1,2- migration of tertiary propargylic alcohols.
