61453-97-2

Upstream product

• 949101-24-0 acetic acid 3-phenyl-1-(pyridin-2-yl)prop-2-ynyl ester 
• 949101-41-1 acetic acid indolizin-1-yl ester 
• 98-09-9 benzenesulfonyl chloride 
• 1122-62-9 2-acetylpyridine 
• 108-24-7 acetic anhydride 
• 5337-53-1 3-phenyl-1-(2-pyridyl)prop-2-en-1-one 
• 536-74-3 phenylacetylene 
• 1121-60-4 pyridine-2-carbaldehyde 
• 915707-84-5 3-phenyl-1-pyridin-2-ylprop-2-yn-1-ol 

Relevant academic research and scientific papers

Copper-Catalyzed Carbon-Nitrogen/Carbon-Selenium Bonds Formation: Synthesis of 2-(Organochalcogenyl)-indolizines

The copper-catalyzed cyclization of propargylpyridines with diorganyl dichalcogenides was applied to the synthesis of 2-(organochalcogenyl)-indolizines. A systematic study of the cyclization system revealed that the mutual action between copper(I) iodide

Desulfitative palladium-catalyzed direct C-3 arylation of indolizines with arylsulfonyl chlorides

An efficient Pd-catalyzed desulfitative approach to C-3 arylation of indolizine derivatives has been developed, and the protocol uses readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation was performed in a mixed solvent of 1-methyl-2-pyrrolidone and dimethoxyethane using simple triphenylphosphine as a ligand, which provides a new method for the C-3 arylation of indolizines. An efficient Pd-catalyzed desulfitative approach to C-3 arylation of indolizine derivatives has been developed, the protocol using readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation proceeds in a mixed solvent of NMP and DME using simple triphenylphosphine a ligand, and provides a new method for the C-3 arylation of indolizines.

Intramolecular C-N bond formation under metal-free conditions: Synthesis of indolizines

Polysubstituted indolizine derivatives are constructed via intramolecular C-N bond formation/C-H bond cleavage under metal-free conditions. These methods offer straightforward pathways to transform pyridyl chalcones into a variety of indolizines.

Multisubstituted N-fused heterocycles via transition metal-catalyzed cycloisomerization protocols

Two complementary protocols for assembly of multisubstituted N-fused heterocycles have been developed. It was demonstrated that 1,3-disubstituted N-fused heterocycles, including indolizines, pyrroloquinoxalines, and pyrrolothiazoles can easily be synthesized via an exceptionally mild and efficient method involving a novel silver-catalyzed cycloizomerization of propargyl-containing heterocycles. Alternatively, 1,2-disubstituted heterocycles can be accessed through the novel cascade transformation involving an alkyne-vinylidene isomerization with concomitant 1,2-shift of hydrogen, silyl, stannyl, or germyl groups. This mild and simple method allows for selective and highly efficient synthesis of indolizines, pyrroloisoquinolines, pyrroloquinoxalines, pyrrolopyrazines, and pyrrolothiazoles.

Base- and ligand-free room-temperature synthesis of N-fused heteroaromatic compounds via the transition metal-catalyzed cycloisomerization protocol

A new practical method for the synthesis of N-fused heterocycles via the transition metal-catalyzed cycloisomerization of heterocyles possessing a propagyl group has been developed. This very mild, base- and ligand-free method allows for the synthesis of diverse fused heterocyclic cores in good to excellent yields.

Highly efficient synthesis of functionalized indolizines and indolizinones by copper-catalyzed cycloisomerizations of propargylic pyridines

(Chemical Equation Presented) The copper-catalyzed cycloisomerizations of 2-pyridyl-substituted propargylic acetates and its derivatives are described, which offer an efficient route to C-1 oxygenated indolizines with a wide range of substituents under mild reaction conditions. The presented method could be readily applied to the synthesis of indolizinones through a cyclization/1,2- migration of tertiary propargylic alcohols.

A novel and efficient approach to highly substituted indolizines via 5-endo-trig iodocyclization

A new approach to indolizines has been developed using a 5-endo-trig iodocyclization of allylic esters followed by isomerization and dehydroiodination facilitated by triethylamine at rt. This mild procedure enabled us to synthesize a number of highly subs