949925-06-8

Upstream product

• 71657-88-0 (4R)-4-phenyl-2-pyrrolidone 
• 105-36-2 ethyl bromoacetate 
• 102-96-5 (2-nitroethenyl)benzene 
• 22975-21-9 (R)-1,3-diethyl 2-(2-nitro-1-phenylethyl)malonate 
• 1443453-37-9 ethyl (4R)-2-oxo-4-phenylpyrrolidine-3-carboxylate 

Downstream Products

• 949925-07-9 2-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide 

Relevant academic research and scientific papers

Enantioselective synthesis of γ-aminobutyric acid derivatives by Ni(II)-catalyzed reaction of diethyl malonate with nitroalkenes

A new synthetic approach to (3R)-4-amino-3-methylbutyric acid and [(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide [(R)-phenotropil] has been developed. Asymmetric center with a required configuration has been generated via enantioselective addition of dieth

N-Carbamoylmethyl-4-(R)-Phenyl-2-Pyrrolidinone, Method of its Preparation and Pharmaceutical Use

The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence