949925-07-9

Usage

Chiral compound

(4R)designation

Derivative of pyrrolidine

2-oxo-4-phenyl moiety attached

Potential pharmaceutical applications

may be used as a building block in the synthesis of other organic compounds

Importance of stereochemistry

determines biological activity and potential pharmaceutical use

Upstream product

• 949925-06-8 ethyl [(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetate 
• 71657-88-0 (4R)-4-phenyl-2-pyrrolidone 
• 1443453-37-9 ethyl (4R)-2-oxo-4-phenylpyrrolidine-3-carboxylate 
• 22975-21-9 (R)-1,3-diethyl 2-(2-nitro-1-phenylethyl)malonate 
• 102-96-5 (2-nitroethenyl)benzene 
• 1402044-28-3 n-butyl 3(R)-4-amino-3-phenylbutyrate hydrochloride 
• 1402044-31-8 n-butyl (3R)-4-cyanomethylamino-3-phenylbutyrate 
• 1402044-29-4 n-butyl (3R)-4-carbamoylmethylamino-3-phenylbutyrate 

Relevant academic research and scientific papers

Enantioselective synthesis of γ-aminobutyric acid derivatives by Ni(II)-catalyzed reaction of diethyl malonate with nitroalkenes

A new synthetic approach to (3R)-4-amino-3-methylbutyric acid and [(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide [(R)-phenotropil] has been developed. Asymmetric center with a required configuration has been generated via enantioselective addition of dieth

Novel methods for the synthesis of 2-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]- acetamide ((R)-phenotropil)

Two novel methods have been developed for the preparation of 2-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide ((R)-Phenotropil). In the first, n-butyl (3R)-4-amino-3-phenylbutyrate is alkylated with haloacetamide in DMF in the presence of potassium phospha

N-Carbamoylmethyl-4-(R)-Phenyl-2-Pyrrolidinone, Method of its Preparation and Pharmaceutical Use

The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence