71657-88-0

Basic information

• Product Name: (R)-4-Phenylpyrrolidin-2-one
• Synonyms: (R)-4-Phenylpyrrolidin-2-one
• CAS NO: 71657-88-0
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.20044
• Mol File: 71657-88-0.mol
• Article Data: 28

Chemical Properties

• Melting Point: 101-104 °C
• Boiling Point: 362.3±31.0 °C(Predicted)
• Appearance: /
• Density: 1.108±0.06 g/cm3(Predicted)
• PKA: 16.13±0.40(Predicted)
• CAS DataBase Reference: (R)-4-Phenylpyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-Phenylpyrrolidin-2-one(71657-88-0)
• EPA Substance Registry System: (R)-4-Phenylpyrrolidin-2-one(71657-88-0)

Safety Data

• Hazardous Substances Data: 71657-88-0(Hazardous Substances Data)

Usage

General Description

(R)-4-Phenylpyrrolidin-2-one, also known as (R)-P4-MPPA, is a chemical compound belonging to the class of pyrrolidinone derivatives. It is a chiral molecule with a phenyl group attached to the pyrrolidinone ring. (R)-4-Phenylpyrrolidin-2-one has been studied for its potential pharmacological properties, including its use as a precursor in the synthesis of pharmaceuticals and bioactive compounds. It has also been investigated for its role as an intermediate in the production of organic compounds. (R)-4-Phenylpyrrolidin-2-one's unique structure and properties make it an important building block in organic chemistry and drug development.

Upstream product

• 135056-44-9 (αR,4R)-1-(1'-phenylethyl)-4-phenylpyrrolidin-2-one 
• 138782-42-0 (3R,4R)-N-<(1R)-2-Hydroxy-1-phenylethyl>-2-oxo-4-phenylpyrrolidine-3-carboxamide 
• 145549-06-0 (R)-1-((S)-2-Hydroxy-1-phenyl-ethyl)-4-phenyl-pyrrolidin-2-one 
• 174618-44-1 (R)-1-(4-methoxyphenyl)-4-phenylpyrrolidin-2-one 
• 67-56-1 methanol 
• 52950-37-5 (R)-4-amino-3-phenylbutanoioc acid hydrochloride 
• 537676-64-5 ethyl 4-azido-3-(4-chlorophenyl)-2-butenoate 
• 1198-97-6 4-phenylpyrrolidin-2-one 
• 99-91-2 para-chloroacetophenone 
• 185067-05-4 ethyl 2-carbethoxy-3-cyano-3-phenylpropionate 
• 5153-67-3 nitrostyrene 
• 252248-89-8 N-cinnamoylpyrrole[1-(pyrrol-1'-yl)-3-phenylprop-2E-enone] 
• 894421-56-8 (Z)-ethyl 4-azido-3-phenylbut-2-enoate 
• 52784-31-3 3-Phenylcyclobutanone 

Downstream Products

• 61586-46-7 (-)-(R)-3-Phenylpyrrolidine 
• 949925-07-9 2-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide 
• 52950-37-5 (R)-4-amino-3-phenylbutanoioc acid hydrochloride 
• 1078-21-3 (R)-Phenibut 
• 1437789-57-5 C₂₆H₂₁N₃O₂ 
• 949925-06-8 ethyl [(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetate 
• 128372-78-1 (+)-(R)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone 

Relevant articles and documents

Enantioselective conjugate addition of an α,α-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)-Pd complexes

The enantioselective conjugate addition reaction of an α,α-dithioacetonitrile with nitroalkenes was catalysed by chiral bis(imidazoline)-palladium pincer-type complexes. The reaction was applicable to various nitroalkenes to afford products in good yield with high enantioselectivity. The obtained products can be converted to γ-lactam and biologically active rolipram.

Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors

N-Methylpyrrolidone is one of several chemotypes that have been described as a mimetic of acetyl-lysine in the development of bromodomain inhibitors. In this paper, we describe the synthesis of a 4-phenyl substituted analogue – 1-methyl-4-phenylpyrrolidin-2-one – and the use of aryl substitution reactions as a divergent route for derivatives. Ultimately, this has led to structurally complex, chiral compounds with progressively improved affinity as inhibitors of bromodomain-containing protein 4.

COMPOUND, MANUFACTURING METHOD OF COMPOUND THROUGH ASYMMETRIC MICHAEL ADDITION USING THE COMPOUND AND MANUFACTURING METHOD OF PHENIBUT USING THE COMPOUND

The present invention relates to a compound, a method of producing compounds through an asymmetric Michael addition reaction by using the same, and a method of producing a phenibut compound. Specifically, the compound of the present invention is represented by chemical formula 1. In the chemical formula 1: L represents #AAA# or #BBB# (wherein X represents sulfur or oxygen); R_1 represents hydrogen, an alkyl group having 1-5 carbons, an aryl group having 6-12 carbon atoms, or a benzyl group; R_2 represents an aryl group having 6-12 carbon atoms; R_3 represents hydrogen or an aryl group having 1-12 carbon atoms; and hydrogen in R_1, R_2, and R_3 may be each independently substituted by an alkyl group having 1-5 carbon atoms.COPYRIGHT KIPO 2018