94995-57-0

Upstream product

• 829-85-6 diphenylphosphane 
• 140-88-5 ethyl acrylate 
• 100-52-7 benzaldehyde 
• 65567-06-8 lithium diphenylphosphide 
• 678187-53-6 (tert-butyldimethylsilyl)diphenylphosphine 

Downstream Products

• 117917-31-4 {Ru3(CO)9(μ3-η2-C2tBu)}2(μ4-Hg){Ru3(CO)8(μ3-.eta2-C2tBu)(PPh3(CH2CH2COOC2H5))} 
• 117917-32-5 {Ru3(CO)9(μ3-η2-C2tBu)(PPh3(CH2CH2COOC2H5))}2(μ4-Hg) 

Relevant academic research and scientific papers

Copper(I) complexes with remotely functionalized phosphine ligands: Synthesis, structural variety, photophysics and effect onto the optical properties

The synthesis, chemical and photophysical investigation of a series of eight novel copper-halide derivatives with different nuclearity is herein presented. One mononuclear copper(I) complex with formula [CuI(pyridine)(P)2], where P is a functio

Catalyst-free hydrophosphination of alkenes in presence of 2-methyltetrahydrofuran: A green and easy access to a wide range of tertiary phosphines

A hydrophosphination reaction that is free of base, acid and catalyst, using only 2-methyltetrahydrofuran as additive has been performed. A new family of mono-, di-, tri- and tetra-phosphines compounds are obtained in good to excellent yields by adding di

Photocatalytic Hydrophosphination of Alkenes and Alkynes Using Diphenylphosphine and Triamidoamine-Supported Zirconium

Reactions of alkene or alkyne with diphenylphosphine and catalytic [κ5-N,N,N,N,C-(Me3SiNCH2CH2)2NCH2CH2NSiMe2CH2]Zr (1) are greatly enhanced under photolysis, providing viable catalytic hydrophosphination with a broad substrate scope. Whereas diphenylphosphine had been an inaccessible substrate under thermal conditions, complete conversion of alkene substrates to tertiary phosphine is achieved in as little as four hours at ambient temperature with 1 under ultraviolet irradiation. Previously inactive alkenes are now hydrophosphination substrates with diphenylphosphine to produce tertiary phosphine ligands possessing tunable steric and electronic properties.

Rosuvastatin intermediate compound and preparation method and application thereof

The invention relates to an intermediate compound for preparation of rosuvastatin calcium. A structure of the intermediate compound is shown as a formula (I), and the intermediate compound is stable and high in nucleophilicity and reaction activity. In addition, the invention further relates to a preparation process suitable for industrial production of rosuvastatin calcium. Due to adoption of the intermediate compound, a rosuvastatin calcium preparation method is mild in reaction condition, free of ultralow-temperature equipment, simple in aftertreatment and easy in operation, and intermediate product olefin which is an intermediate compound shown as a formula (III) is high in stereoselectivity and yield, high in product quality and high in economic benefit.

Visible Light Photocatalysis Using a Commercially Available Iron Compound

[CpFe(CO)2]2 (1) (Cp = η5-C5H5) is an effective precatalyst for the hydrophosphination of alkenes with Ph2PH under visible light irradiation, which appears to be a unique way to promote metal-catalyzed hydrophosphination. Additionally, 1 is a photocatalyst for the dehydrogenation of amine boranes and formation of siloxanes from tertiary silanes. These reactions have similar, if not improved, reactivity over the same transformations using 1 or related CpFeMe(CO)2 under UV irradiation, consistent with the notion that hydrophosphination with 1 proceeds via formation of CpFe(CO)2?. These results demonstrate that catalyst selection can avail the use of commercially available LED bulbs as photon sources, potentially replacing mercury arc lamps or other energy intensive processes in known or new catalytic reactions.

Tin-catalyzed hydrophosphination of alkenes

Simple tin derivatives, Cp?2SnCl2 (1) and Ph2SnCl2 (2), catalyze the hydrophosphination of alkene substrates with diphenylphosphine. Competitive dehydrocoupling to give Ph4P2 was observed, but this side reaction can be mitigated when the catalysis is conducted under an H2 atmosphere. Efforts to prepare stable tin bis(phosphido) compounds commonly resulted in decomposition to Ph4P2. Lewis acidic inorganic tin compounds do not show dehydrocoupling reactivity. It was found that the Lewis acid, B(C6F5)3, is able to engage in the hydrophosphination of alkenes, but it is poorly effective under the conditions tested.

Catalyst- and solvent-free hydrophosphination and multicomponent hydrothiophosphination of alkenes and alkynes

The hydrophosphination of carbon-carbon multiple bonds has been generally performed under acid, base or metal catalysis in different solvents. Herein, alkyl and alkenyl tertiary phosphines are obtained by the addition of diphenylphosphine to alkenes and alkynes, respectively, in the absence of a solvent and a catalyst. In the presence of elemental sulfur, the corresponding alkyl and alkenyl tertiary phosphine sulfides are synthesized in a three-component process. These simple methods, which meet most of the principles of Green Chemistry, are highly regioselective towards the anti-Markovnikov products and diastereoselective towards the Z alkenyl phosphines. The mechanistic aspects of the reactions are also tackled and the efficiency of the latter is compared with that of the catalytic methods.

Solvent- and catalyst-free regioselective hydrophosphanation of alkenes

The hydrophosphanation of alkenes, an atom-economy process typically promoted by radicals or metal species, has been shown to take place in the absence of a catalyst, under solvent-free conditions and in a regioselective manner.

Regio- and stereoselective synthesis of alkenylphosphines: A rhodium-catalyzed hydrophosphination of alkynes using a silylphosphine

(Chemical Equation Presented) A novel rhodium-catalyzed hydrophosphination of alkynes using a silylphosphine as a phosphino group source is described. A variety of alkynes, both terminal and internal ones with aryl, alkyl, and carboxyl groups, gave the co

Fluoride-catalyzed three-component coupling reaction of a silylphosphine, activated alkenes and aldehydes

A novel CsF-catalyzed three-component coupling reaction of a silylphosphine, activated alkenes and aldehydes is described. Multi-functional phosphines were obtained by forming both carbon-phosphorus and carbon-carbon bonds in good yields under mild conditions.