95005-60-0Relevant academic research and scientific papers
Mannich-Type Reactions of Aldehydes, Amines, and Ketones in a Colloidal Dispersion System Created by a Bronsted Acid-Surfactant-Combined Catalyst in Water
Manabe, Kei,Kobayashi, Shu
, p. 1965 - 1967 (1999)
(matrix presented) Three-component Mannich-type reactions of aldehydes, amines, and ketones were efficiently catalyzed by dodecylbenzenesulfonic acid at ambient temperature in water to give various β-amino ketones in good yields. The same reactions proceeded sluggishly in organic solvents.
Mannich-type reactions of aromatic aldehydes, anilines, and methyl ketones in fluorous biphase systems created by rare earth (III) perfluorooctane sulfonates catalysts in fluorous media
Yi, Wen-Bin,Cai, Chun
, p. 1515 - 1521 (2008/09/16)
Rare earth (III) perfluorooctane sulfonates (RE(OPf)3) catalyze the three-component Mannich-type reactions of different ketones with various aromatic aldehydes and aromatic amines in fluorous media to give various β-arylamino ketones in good yields. By simple separation of the fluorous phase containing only catalyst, reaction can be repeated several times.
Three-component carbon-carbon bond-forming reactions catalyzed by a Br?nsted acid-surfactant-combined catalyst in water
Manabe, Kei,Mori, Yuichiro,Kobayashi, Shu
, p. 2537 - 2544 (2007/10/03)
Reactions of aldehydes, amines, and various nucleophiles such as silyl enolates, ketones, Danishefsky's diene, and allyltribuyltin in water were successfully carried out in the presence of p-dodecylbenzenesulfonic acid (DBSA) as a Br?nsted acid-surfactant-combined catalyst.
Aldehydes vs aldimines. Unprecedented aldimine-selective nucleophilic additions in the coexistence of aldehydes using a lanthanide salt as a Lewis acid catalyst
Kobayashi, Shu,Nagayama, Satoshi
, p. 10049 - 10053 (2007/10/03)
It is well-recognized that aldimines are less reactive than aldehydes toward nucleophilic additions. In this paper, an unprecedented change in the reactivity is described: preferential reactions of aldimines over aldehydes in nucleophilic additions using
