951008-07-4Relevant academic research and scientific papers
Total synthesis of (-)-ecklonialactone B
Becker, Julia,Butt, Lena,Von Kiedrowski, Valeska,Mischler, Elisabeth,Quentin, Florian,Hiersemann, Martin
, p. 5982 - 5985 (2014/01/06)
The total synthesis of (-)-ecklonialactone B as well as the 9,10-dihydro derivative by two different strategies is reported. The catalytic asymmetric Claisen rearrangement of Gosteli-type allyl vinyl ethers delivered elaborated α-keto ester building blocks. Ring-closing metatheses, including a notable diastereotopos-differentiating variant, a B-alkyl Suzuki-Miyaura cross-coupling reaction and a regio- and diastereoselective last-step epoxidation are key contributors.
The catalytic asymmetric claisen rearrangement (CAC) in natural product synthesis: Synthetic studies toward (-)-ecklonialactone B
Wang, Qi,Millet, Agnès,Hiersemann, Martin
, p. 1683 - 1686 (2008/02/07)
A catalytic asymmetric Claisen rearrangement (CAC) in concert with a ring-closing metathesis (RCM) has been utilized in the enantioselective synthesis of the C10-C18 segment of ecklonialactone B. Georg Thieme Verlag Stuttgart.
