95205-67-7Relevant articles and documents
Efficient synthesis of the tetracyclic aminoquinone moiety of marmycin A
Maugel, Nathan,Snider, Barry B.
, p. 4926 - 4929 (2009)
An efficient four-step route to the tetracyclic aminoquinone moiety of marmycin A that proceeds in 41% overall yield from 5-nitronaphthoquinone and 5-methy 1-1-vinylcyclohexene will facilitate preparation of marmycin A analogues for biological evaluation.
Antiandrogenic, maspin induction, and antiprostate cancer activities of tanshinone IIA and its novel derivatives with modification in ring A
Liu, Weiguo,Zhou, Jinming,Geng, Guoyan,Shi, Qingwen,Sauriol, Francoise,Wu, Jian Hui
supporting information; experimental part, p. 971 - 975 (2012/03/11)
Expression of metastatic suppressor maspin is lost in advanced prostate cancer. Clinically relevant mutations in androgen receptor (AR) convert antiandrogens into AR agonists, promoting prostate tumor growth. We discovered tanshinone IIA (TS-IIA) is a potent antagonist of mutated ARs and induces maspin expression through AR. TS-IIA suppressed AR expression and induced apoptosis in LNCaP cells. Syntheses of TS-IIA derivatives (1-9) revealed that the 4,4-dimethyl group at ring A is important for TS-IIA's antiandrogenic and maspin induction activities.
α-HALOALKANESULFONYL BROMIDES IN ORGANIC SYNTHESIS. 4. REGIOSELECTIVE γ-DEPROTONATION OF α,β-UNSATURATED SULFONES. A SIMPLE SYNTHESIS OF 2-ALKYL-1,3-BUITADIENES
Block, Eric,Eswarakrishnan, Venkatachalam,Gebreyes, Kassu
, p. 5469 - 5472 (2007/10/02)
A simple method for converting 2-methyl-1-alkenes into 2-alkyl-1,3-butadienes is described.Evidence for complexation of lithium cations by sulfonyl groups in the course of reactions of α,β-unsaturated sulfones with LiOt-Bu is presented.
