95215-69-3

Usage

Class

Pyridinones

Use in pharmaceutical industry

Chelating agent for treating metal ion overload conditions (e.g. iron overload in patients receiving blood transfusions)

Property

Strong metal-binding ability

Application

Removing excess metal ions from the body to treat metal toxicity-related diseases

Potential use

Agriculture and environmental remediation for binding and removing heavy metals from soil and water.

Upstream product

• 60-35-5 acetamide 
• 32656-34-1 cis-4-oxo-pentenedial 
• 16867-04-2 dihydroxypyridine 
• 506-96-7 Acetyl bromide 

Relevant academic research and scientific papers

Synthesis of 3-hydroxypyrid-2-ones from furfural for treatment against iron overload and iron deficiency

Derivatives of 3-hydroxypyrid-2-ones, which posses very high affinity for iron and have anomalous applications in iron overload and iron deficiency, were prepared from furfural in simple reaction conditions.

Iron-pyridone complexes for anemia

Pharmaceutical compositions containing an iron complex of a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, are of value for the treatment of iron deficiency anemia.

Pharmaceutical compositions

Pharmaceutical compositions containing a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, or a salt thereof containing a physiologically acceptable ion or ions, are of value for removing toxic amounts of metals, particularly iron, from the body.