95276-54-3

Upstream product

• 124-41-4 sodium methylate 
• 94-41-7 benzalacetophenone 
• 105-34-0 methyl 2-cyanoacetate 
• 67-56-1 methanol 
• 79-20-9 acetic acid methyl ester 
• 861317-48-8 2-benzoyl-1-cyano-3-phenyl-cyclopropanecarboxylic acid methyl ester 
• 614-47-1 1,3-diphenyl-propen-3-one 

Downstream Products

• 861324-43-8 2,4-dibromo-2-cyano-5-oxo-3,5-diphenyl-valeric acid methyl ester 
• 861317-48-8 2-benzoyl-1-cyano-3-phenyl-cyclopropanecarboxylic acid methyl ester 
• 89649-52-5 3,5-diphenylpyrrole-2-carboxylate de methyle 
• 1148157-87-2 methyl 3,5-diphenylthiophene-2-carboxylate 
• 1373319-68-6 methyl 1-benzyl-3,5-diphenyl-1H-pyrrole-2-carboxylate 
• 1373319-67-5 C₃₁H₂₆N₂O 
• 1292310-23-6 methyl 2,5-dioxo-3,5-diphenylpentanoate 
• 85936-84-1 benzoyl-4 phenyl-3 butyro nitrile 
• 94905-50-7 2-oxo-4,6-diphenyl-1,2,3,4-tetrahydro-pyridine-3-carboxylic acid 
• 5456-53-1 5-oxo-3,5-diphenylpentanoic acid 
• 116597-46-7 2-cyano-5-oxo-2-(3-oxo-1,3-diphenyl-propyl)-3,5-diphenyl-valeric acid methyl ester 
• 861310-92-1 2-bromo-2-cyano-5-oxo-3,5-diphenyl-valeric acid methyl ester 
• 93729-27-2 2-cyano-5-oxo-3,5-diphenyl-valeric acid 
• 332072-07-8 2-bromo-4,6-diphenyl-nicotinic acid methyl ester 

Relevant academic research and scientific papers

An active and selective heterogeneous catalytic system for Michael addition

Potassium fluoride doped natural zeolite was found to be an efficient and selective solid base catalyst for 1,4-Michael addition. The catalyst is easily prepared and the workup procedure simplified by simple filtration. All products were obtained in high

Facile regiocontrolled three-step synthesis of poly-substituted furans, pyrroles, and thiophenes: Consecutive michael addition of methyl cyanoacetate to α,β-enone, CuI-mediated aerobic oxidation, and acid-catalyzed paal-knorr synthesis

An efficient synthesis of poly-substituted furans, pyrroles, and thiophenes was carried out in a regiocontrolled manner via a three-step process; (i) conjugate addition of methyl cyanoacetate derivatives to α,β-enones, (ii) CuI-mediated aerobic oxidation,

Construction of 1,2,5-tricarbonyl compounds using methyl cyanoacetate as a glyoxylate anion synthon combined with copper(I) iodide-catalyzed aerobic oxidation

A practical and efficient synthesis of various 1,2,5-tricarbonyl compounds is described. The synthesis has been carried out by a conjugate addition of methyl cyanoacetate to the β-position of α,β-unsaturated carbonyl compounds and a subsequent copper(I) iodide-catalyzed aerobic oxidation. In addition, various α-aryl- and α-alkyl-α-keto esters have been synthesized using a similar approach. Copyright

Natural phosphate modified with lithium nitrate: A new efficient catalyst for the construction of carbon-carbon, carbon-sulfur, and carbon-nitrogen bonds

The addition of small amounts of lithium nitrate to natural phosphate followed by calcination gives a new catalyst Li/NP (weight ratio LiNO3/NP = 1/15). This material showed catalytic activity in the Michael addition of amines, mercaptans, and active methylene compounds to chalcone derivatives with high yields under mild reaction conditions. Li/NP is used as the catalyst for a facile synthesis of -amino acids, -sulfur acids, and 4 H-chromenes under heterogeneous conditions. The usual, undesirable byproducts from the Michael condensation such as 1,2-addition, bis-addition, and polymerization compounds are not observed with this method. The work-up procedure is simplified by simple filtration with the use of Li/NP.

Michael additions of methylene active compounds to chalcone in ionic liquids without any catalyst: The peculiar properties of ionic liquids

Michael additions of malonodinitrile as well as several other reagents to chalcone have been found to proceed well in pure ionic liquids, without the addition of any catalyst. The catalytic effect of the residual acidity caused by hydrolysis of ionic liqu

Natural phosphate doped with potassium fluoride: Efficient catalyst for the construction of a carbon-carbon bond

Natural phosphate-doped catalyst was found to be an efficient, environmentally attractive, and selective solid base catalyst for 1,4-Michael addition. The products of undesirable side reactions resulting from 1,2-adddition, polymerization, and bis-additio

Etude de la reaction de Michael en presence de divers agents complexants des cations alcalins en milieu aprotique ou dans les conditions de transfert de phase

Michael addition of methyl cyanoacetate to benzylideneacetophenone 5a or benzylideneacetone 5b, in THF, under LiOt-Bu or KF catalysis takes place only in the presence of complexing agents for the cation.With LiO.t.Bu, HMPA, diHMPA, NIPA or 12-crown-4 show