95388-12-8

Upstream product

• 56234-52-7 1,8-bis(p-toluenesulfonyloxy)-3,6-bis(p-toluenesulfonyl)-3,6-diazaoctane 
• 107-15-3 ethylenediamine 
• 386218-02-6 N,N'-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane hydrobromide 
• 6315-52-2 1,2-bis-tosyloxyethane 
• 52667-89-7 N,N',N-tris(p-toluenesulfonyl)-1,4,7-triazacyclononane 
• 1354021-90-1 1,4-di(tosyl)-1,4,7-triazacyclononane tosylate 
• 106-93-4 ethylene dibromide 

Downstream Products

• 1056967-99-7 1,2-Bis(4-p-toluenesulfonyl-1,4,7-triazacyclonon-1-yl)ethane 

Relevant academic research and scientific papers

1,2-BIS-(4,7-DIMETHYL-1,4,7-TRIAZACYCLONON-1-YL)-ETHANE AND INTERMEDIATE THEREOF

The present invention provides improved processes for the synthesis of 1,4-ditosyl- 1,4,7-triazacyclonone and protected analogues thereof, and to synthesise bis(triazacyclononane) ligands.

METHODS FOR THE SYNTHESIS OF BIS (TRIAZACYCLONONANE) LIGANDS

The present invention provides an improved process to synthesize bis(triazacyclononane) ligands, in which 1,4-di(arylsulfonate)-1,4,7-triazacyclononane is reacted with dihaloethane to produce 1,2-bis(4,7-diarylsulfonate-1,4,7-triazacyclonon-1-yl)-ethane,

Complexes of cyclic polyaza chelators with cations of alkaline earth metals for enhanced biological activity

Cyclic polyaza chelators that possess high affinity and specificity for first transition series metal cations exhibit an unanticipated improvement in biological activity when administered as complexes with cations of the alkaline earth metals, Ca(II) and Mg(II), most notably Ca(II). By virtue of this improvement, these complexes are particularly effective in the treatment of pathological conditions, including ischemia and ischemia-reperfusion injury.

A remarkably efficient and direct route for the synthesis of binucleating 1,4,7-triazacyclononane ligands

An extremely efficient and direct route towards a range of binucleating analogues of 1,4,7-triazacyclononane 5a-f, has been developed. In all cases the reactions of benzylic and aliphatic diamines with ditosylate ester 3 proceed to give the target binucleating ligands ahnost exclusively and in excellent yield.