954-65-4

Upstream product

• 622-24-2 2-phenylethyl chloride 
• 98-88-4 benzoyl chloride 
• 694-87-1 benzocyclobutene 
• 493-05-0 isochromane 
• 4702-34-5 isochroman-1-one 
• 54996-38-2 (2-(2-hydroxyethyl)phenyl)(phenyl)methanone 
• 100-58-3 phenylmagnesium bromide 
• 36374-47-7 1-hydroxy 1-phenyl indane 

Downstream Products

• 22220-39-9 N-(2-benzoyl-phenethyl)-phthalimide 

Relevant academic research and scientific papers

Copper-catalyzed radical ring-opening halogenation with HX

An efficient copper-catalyzed radical ring-opening halogenation with HX (aq) is described. This protocol features redox-neutral conditions, green halogen sources, and a broad substrate scope, providing practical access to distally chlorinated, brominated and iodinated alkyl ketones and alkyl nitriles with moderate to good yields. This journal is

Preparation method of phenyl tetrahydroisoquinoline

The invention provides a preparation method of phenyl tetrahydroisoquinoline, belonging to the field of pharmaceutical chemicals. According to the method, dihydro-1H-2-benzopyran-1-one is used as a starting material and is subjected to Grignard reagent ring opening, chlorination, substitution reaction and hydrazinolysis to obtain a phenyl tetrahydroisoquinoline compound. The compound produced by the method has the characteristics of high purity, high yield, low cost, simple operation and stable process.

Method for preparing solifenacin impurity

The invention discloses a method for preparing a solifenacin impurity. The solifenacin impurity is prepared by synthesizing isochroman serving as an initial raw material through nine steps of reaction. The method has the advantages of reasonable process design, low-price raw materials, mild reaction condition and strong operability. The solifenacin purity has a purity of over 98 percent and yield of over 80 percent, can be used for providing a sample for metabolic mechanism researches of solifenacin, and has an important application value. According to the method, a novel synthesis method is provided, the defects of purifying difficulty, low yield and the like caused by one-pot cooking or ester exchange in the last step of an API method can be effectively avoided, and novel method and thought are provided to API synthesis.