54996-38-2

Upstream product

• 4702-34-5 isochroman-1-one 
• 100-58-3 phenylmagnesium bromide 
• 58668-70-5 2-(o-Benzoylphenyl)acetaldehyde 
• 493-05-0 isochromane 
• 100-59-4 phenylmagnesium chloride 
• 591-51-5 phenyllithium 
• 2292-59-3 3,4-Dihydro-1-phenyl-1H-benzopyran 
• 54673-12-0 (2-(methoxymethoxy)ethyl)benzene 
• 60-12-8 2-phenylethanol 

Downstream Products

• 1224454-78-7 2-benzoylphenethyl adamantanoate 
• 954-65-4 (2-(2-chloroethyl)phenyl)(phenyl)methanone 
• 22990-19-8 1-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Method for preparing 2-hydroxyethyl phenyl ketone through catalytic oxidation of isochroman

The invention relates to a method for preparing 2-hydroxyethyl phenyl ketone through catalytic oxidation of isochroman, which comprises the following steps of dissolving 1-substituted isochroman and an acid or aryl carbocation compound in an organic solvent, uniformly mixing, reacting at preset temperature, and treating with a sodium carbonate water solution to obtain 2-hydroxyethyl phenyl ketone.The method provided by the invention has the advantages of high reaction efficiency, simple operation and high atom economy, avoids the use of expensive or toxic catalysts or assistants, reduces thepollution to the environment, and reduces the cost. The compound synthesized by the invention can be used as a drug synthesis intermediate for synthesizing drugs with the potential of treating epilepsy, spasm, chronic pain and neurodegenerative diseases.

Method for preparing 2-hydroxyethyl phenyl ketone by coupling two components

The invention relates to a method for preparing 2-hydroxyethyl phenyl ketone by coupling two components, which comprises the following steps of dissolving a beta-phenethyl alcohol compound and aldehyde ACHO in an organic solvent, adding an acid, uniformly mixing, and heating to react, thereby obtaining the 2-hydroxyethyl phenyl ketone shown in the formula (2). The raw materials beta-phenethyl alcohol compounds and aldehyde used in the method are simple, easy to obtain and low in cost, isochroman derivative intermediates do not need to be separated, the reaction steps are short, the multi-stepsynthesis process is avoided, operation is easy, atom economy is high, expensive or toxic catalysts are not needed, and environmental pollution is reduced.

Preparation method of phenyl tetrahydroisoquinoline

The invention provides a preparation method of phenyl tetrahydroisoquinoline, belonging to the field of pharmaceutical chemicals. According to the method, dihydro-1H-2-benzopyran-1-one is used as a starting material and is subjected to Grignard reagent ring opening, chlorination, substitution reaction and hydrazinolysis to obtain a phenyl tetrahydroisoquinoline compound. The compound produced by the method has the characteristics of high purity, high yield, low cost, simple operation and stable process.

Iridium-Catalyzed Enantioselective Hydrogenation of Oxocarbenium Ions: A Case of Ionic Hydrogenation

Ionic hydrogenation has not been extensively explored, but is advantageous for challenging substrates such as unsaturated intermediates. Reported here is an iridium-catalyzed hydrogenation of oxocarbenium ions to afford chiral isochromans with high enantioselectivities. A variety of functionalities are compatible with this catalytic system. In the presence of a catalytic amount of the Br?nsted acid HCl, an α-chloroether is generated in situ and subsequentially reduced. Kinetic studies suggest first-order kinetics in the substrate and half-order kinetics in the catalyst. A positive nonlinear effect, together with the half kinetic order, revealed a dimerization of the catalyst. Possible reaction pathways based on the monomeric iridium catalyst were proposed and DFT computational studies revealed an ionic hydrogenation pathway. Chloride abstraction and the cleavage of dihydrogen occur in the same step.

Method for preparing solifenacin impurity

The invention discloses a method for preparing a solifenacin impurity. The solifenacin impurity is prepared by synthesizing isochroman serving as an initial raw material through nine steps of reaction. The method has the advantages of reasonable process design, low-price raw materials, mild reaction condition and strong operability. The solifenacin purity has a purity of over 98 percent and yield of over 80 percent, can be used for providing a sample for metabolic mechanism researches of solifenacin, and has an important application value. According to the method, a novel synthesis method is provided, the defects of purifying difficulty, low yield and the like caused by one-pot cooking or ester exchange in the last step of an API method can be effectively avoided, and novel method and thought are provided to API synthesis.

Structure-reactivity relationships in (2-hydroxyethyl)benzophenone photoremovable protecting Groups

A detailed study of substituent effects on the photochemical conversion of esters of (2-hydroxyethyl)benzophenone to the carboxylic acid was performed with the aim of improving on the reactivity of the parent, which was first reported decades ago. Over 20