Welcome to LookChem.com Sign In|Join Free

CAS

  • or

955360-05-1

4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

955360-05-1 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 955360-05-1 Structure

  • Basic information

    1. Product Name: 4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate
    2. Synonyms: 4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate
    3. CAS NO:955360-05-1
    4. Molecular Formula:
    5. Molecular Weight: 383.552
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 955360-05-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate(955360-05-1)
    11. EPA Substance Registry System: 4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate(955360-05-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 955360-05-1(Hazardous Substances Data)

955360-05-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 955360-05-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,5,3,6 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 955360-05:
(8*9)+(7*5)+(6*5)+(5*3)+(4*6)+(3*0)+(2*0)+(1*5)=181
181 % 10 = 1
So 955360-05-1 is a valid CAS Registry Number.

955360-05-1Relevant articles and documents

The discovery of quinoline based single-ligand human H1and H3receptor antagonists

Procopiou, Panayiotis A.,Ancliff, Rachael A.,Gore, Paul M.,Hancock, Ashley P.,Hodgson, Simon T.,Holmes, Duncan S.,Keeling, Steven P.,Looker, Brian E.,Parr, Nigel A.,Rowedder, James E.,Slack, Robert J.

, p. 5855 - 5859 (2016/12/06)

A novel series of potent quinoline-based human H1and H3bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis associated nasal congestion, were identified. Com

The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis

Procopiou, Panayiotis A.,Browning, Christopher,Buckley, Jennifer M.,Clark, Kenneth L.,Fechner, Lise,Gore, Paul M.,Hancock, Ashley P.,Hodgson, Simon T.,Holmes, Duncan S.,Kranz, Michael,Looker, Brian E.,Morriss, Karen M. L.,Parton, Daniel L.,Russell, Linda J.,Slack, Robert J.,Sollis, Steven L.,Vile, Sadie,Watts, Clarissa J.

supporting information; experimental part, p. 2183 - 2195 (2011/06/10)

A series of potent phthalazinone-based human H1 and H 3 bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis, were identified. Blockade of H3 receptors is thought to improve efficacy on nasal congestion, a symptom of allergic rhinitis that is currently not treated by current antihistamines. Two analogues (56a and 56b) had slightly lower H1 potency (pA2 9.1 and 8.9, respectively, vs 9.7 for the clinical gold-standard azelastine, and H3 potency (pK i 9.6 and 9.5, respectively, vs 6.8 for azelastine). Compound 56a had longer duration of action than azelastine, low brain penetration, and low oral bioavailability, which coupled with the predicted low clinical dose, should limit the potential of engaging CNS-related side-effects associated with H 1 or H3 antagonism.

2-SUBSTITUTED 4-BENZYLPHTHALAZINONE DERIVATIVES AS HISTAMINE H1 AND H3 ANTAGONISTS

-

Page/Page column 76, (2008/06/13)

The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 955360-05-1