956102-58-2

Basic information

• Product Name: 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine
• Synonyms: 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine
• CAS NO: 956102-58-2
• Molecular Weight: 253.365
• Mol File: 956102-58-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 349.5±35.0 °C(Predicted)
• Density: 1.160±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine(956102-58-2)
• EPA Substance Registry System: 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine(956102-58-2)

Safety Data

• Hazardous Substances Data: 956102-58-2(Hazardous Substances Data)

Upstream product

• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 563-78-0 2,3-Dimethyl-1-butene 
• 70-55-3 toluene-4-sulfonamide 
• 127-65-1 chloroamine-T 

Downstream Products

• 956102-61-7 benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2S)-2,3-dimethyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate 
• 1207755-27-8 benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate 

Relevant articles and documents

Copper-Catalyzed Aziridination with Redox-Active Ligands: Molecular Spin Catalysis

Small-molecule catalysts as mimics of biological systems illustrate the chemists’ attempts at emulating the tantalizing abilities displayed by nature's metalloenzymes. Among these innate behaviors, spin multistate reactivity is used by biological systems as it offers thermodynamic leverage towards challenging chemical reactivity but this concept is difficult to translate into the realm of synthetic organometallic catalysis. Here, we report a rare example of molecular spin catalysis involving multistate reactivity in a small-molecule biomimetic copper catalyst applied to aziridination. This behavior is supported by spin state flexibility enabled by the redox-active ligand.

ANTIFUNGAL AGENTS

Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (l,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs,,as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.

ANTIFUNGAL AGENTS

The present invention relates to novel enfumafungin derivatives of Formula IV-IA and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitorspf(r,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts therp?τ, as WeILaS1Sy-pharmaceutical compositions comprising the present compounds and pharmaceuticalty acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.