2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine

Base Information

• Chemical Name: 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine
• CAS No.: 956102-58-2
• Molecular Formula: C₁₃H₁₉NO₂S
• Molecular Weight: 253.365
• Mol file: 956102-58-2.mol

Synonyms:2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine

Chemical Property of 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine

Chemical Property:

• Boiling Point: 349.5±35.0 °C(Predicted)
• Density: 1.160±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine

There total 3 articles about 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

[N-(p-tolylsulfonyl)imino]phenyliodinane (55962-05-5) + 2,3-Dimethyl-1-butene (563-78-0) → 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine (956102-58-2)

Guidance literature:

With Cu(C₆H₅NC₆H₂(C(CH₃)3)2O)2; In acetonitrile; at 20 ℃; for 5h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201705649

Reference yield:

chloroamine-T (127-65-1) + 2,3-Dimethyl-1-butene (563-78-0) → 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine (956102-58-2)

Guidance literature:

chloroamine-T; 2,3-Dimethyl-1-butene; In acetonitrile; at 20 ℃; for 1.5h;

With phenyltrimethylammonium tribromide; In acetonitrile; at 20 - 26 ℃; for 48h;

Reference yield:

toluene-4-sulfonamide (70-55-3) → 2-isopropyl-2-methyl-1-[(4-methyl-phenyl)sulfonyl]aziridine (956102-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / methanol / 7 h / 0 - 20 °C

2: Cu(C₆H₅NC₆H₂(C(CH₃)3)2O)2 / acetonitrile / 5 h / 20 °C / Schlenk technique; Inert atmosphere

With Cu(C₆H₅NC₆H₂(C(CH₃)3)2O)2; potassium hydroxide; In methanol; acetonitrile;

DOI:10.1002/chem.201705649

upstream raw materials:

chloroamine-T

2,3-Dimethyl-1-butene

toluene-4-sulfonamide

[N-(p-tolylsulfonyl)imino]phenyliodinane

Downstream raw materials:

benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2S)-2,3-dimethyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate

benzyl (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[(2R)-2,3-dimethyl-2-[[(4-methylphenyl)sulfonyl]amino]butyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylate

Refernces

• 1、 -. "ANTIFUNGAL AGENTS". Page/Page column 31-32. . Retrieved 2010/04/03.
• 2、 -. "ANTIFUNGAL AGENTS". Page/Page column 39. . Retrieved 2010/04/03.