956104-45-3

Basic information

• Product Name: 5-((4-Methoxybenzyl)amino)-3-(trifluoromethyl)picolinonitrile
• Synonyms: 5-((4-Methoxybenzyl)amino)-3-(trifluoromethyl)picolinonitrile
• CAS NO: 956104-45-3
• Molecular Weight: 307.275
• Mol File: 956104-45-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-((4-Methoxybenzyl)amino)-3-(trifluoromethyl)picolinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-((4-Methoxybenzyl)amino)-3-(trifluoromethyl)picolinonitrile(956104-45-3)
• EPA Substance Registry System: 5-((4-Methoxybenzyl)amino)-3-(trifluoromethyl)picolinonitrile(956104-45-3)

Safety Data

• Hazardous Substances Data: 956104-45-3(Hazardous Substances Data)

Upstream product

• 22245-83-6 3-(trifluoromethyl)pyridin-2-ol 
• 887707-25-7 2-chloro-5-iodo-3-(trifluoromethyl)pyridine 
• 887707-23-5 2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine 
• 956104-44-2 6-chloro-N-[(4-methoxyphenyl)methyl]-5-(trifluoromethyl)pyridin-3-amine 
• 557-21-1 dicyanozinc 
• 557-21-1 zinc(II) cyanide 

Downstream Products

• 573762-62-6 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile 
• 1332388-83-6 ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate 
• 1332388-84-7 5-(5-(4-bromo-3-fluorophenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile 
• 1332392-79-6 5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile 
• 1332390-03-0 5-(5-(3-fluoro-4-(2-(1-methyl-1H-pyrazol-5-yl)ethoxy)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile 
• 1332390-04-1 5-[8-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5-oxo-7-thioxo-6,8-diazaspiro[3.4]octan-6-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile 
• 1332390-05-2 5-(5-(4-(benzyloxy)-3-fluorophenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile 
• 1332390-80-3 5-(5-(3-fluoro-4-methoxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile 
• 1332391-04-4 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoic acid 
• 1332391-11-3 4-[6-[6-cyano-5-(trifluoromethyl)-3-pyridyl]-5-oxo-7-thioxo-6,8-diazaspiro[3.4]octan-8-yl]-2-fluorobenzamide 
• 1332391-14-6 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(2-(pyrrolidin-1-yl)ethyl)benzamide 
• 1332391-15-7 N-benzyl-4-[6-[6-cyano-5-(trifluoromethyl)-3-pyridyl]-5-oxo-7-thioxo-6,8-diazaspiro[3.4]octan-8-yl]-2-fluorobenzamide 
• 1332391-16-8 4-[6-[6-cyano-5-(trifluoromethyl)-3-pyridyl]-5-oxo-7-thioxo-6,8-diazaspiro[3.4] octan-8-yl]-2-fluoro-N-[2-(2-pyridyl)ethyl]benzamide 
• 1332391-17-9 4-[6-[6-cyano-5-(trifluoromethyl)-3-pyridyl]-5-oxo-7-thioxo-6,8-diazaspiro[3.4]octan-8-yl]-2-fluoro-N-(3-pyrrolidin-1-ylpropyl)benzamide 

Relevant articles and documents

DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST

The present application belongs to the field of medicine. In particular, the present application relates to a diarylthiohydantoin compound as an androgen receptor antagonist or a pharmaceutically acceptable salt thereof, a preparation method of the same, a pharmaceutical composition comprising the compound, and a use thereof in treating a cell proliferative disease mediated by androgen. The compound of the present application has good antagonistic effect on androgen receptor and exhibits excellent antitumor effect.

Substituted diazaspiroalkanes as androgen receptor modulators

This invention provides for compounds of the Formula II: wherein A, B, Het, R1, R2 and R3 are as described herein. These compounds are androgen receptor modulators useful for the treatment of androgen receptor-associated conditions.

SYNTHESIS OF THIOHYDANTOINS

A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.