95623-28-2Relevant academic research and scientific papers
Facile synthesis of Hantzsch 1,4-dihydropyridines with unsymmetrical 2,6-and 3,5-substituents
Wang, Zhen,Liu, Qingjian,Zhang, Wenwen,Chen, Qing
, p. 748 - 750 (2014/01/23)
A facile synthesis of Hantzsch 1,4-dihydropyridines with unsymmetrical 2,6- and 3,5-substituents in a one-pot two-step tandem reaction under solvent-free conditions, promoted by microwave irradiation, has been developed. No catalysts are used and the work-up is easy. This approach provides a convenient, efficient and practical synthesis of 1,4-dihydropyridines having non-identical substituents at the 2,6- and 3,5- positions, which are not easily accessed by the classical Hantzsch synthesis.
Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4- dihydropyridines as highly selective A3 adenosine receptor antagonists
Jiang, Ji-Long,Van Rhee, A. Michiel,Chang, Louis,Patchornik, Abraham,Ji, Xiao-Duo,Evans, Patricia,Melman, Neli,Jacobson, Kenneth A.
, p. 2596 - 2608 (2007/10/03)
4-(Phenylethynyl)-6-phenyl-1,4-dihydropyridine derivatives are selective antagonists at human A3 adenosine receptors, with K(i) values in a radioligand binding assay vs [125I]AB-MECA (N6(4-amino-3-iodobenzyl)-5'- (N-methylcarbamoyl)adenosine) in the submicromolar range. In this study, structure-activity relationships at various positions of the dihydropyridine ring (the 3- and 5-acyl substituents, the 4-aryl substituent, and 1-methyl group) were probed synthetically. Using the combined protection of the 1- ethoxymethyl and the 5-[2-(trimethylsilyl)ethyl] ester groups, a free carboxylic acid was formed at the 5-position allowing various substitutions. Selectivity of the new analogues for cloned human A3 adenosine receptors was determined vs radioligand binding at rat brain A1 and A(2A) receptors. Structure-activity analysis at adenosine receptors indicated that pyridyl, furyl, benzofuryl, and thienyl groups at the 4-position resulted in, at most, only moderate selectivity for A3 adenosine receptors. Ring substitution (e.g., 4-nitro) of the 4-phenylethynyl group did not provide enhanced selectivity, as it did for the 4-styryl-substituted dihydropyridines. At the 3-position of the dihydropyridine ring, esters were much more selective for A3 receptors than closely related thioester, amide, and ketone derivatives. A cyclic 3-keto derivative was 5-fold more potent at A3 receptors than a related open-ring analogue. At the 5-position, a homologous series of phenylalkyl esters and a series of substituted benzyl esters were prepared and tested. (Trifluoromethyl)-, nitro-, and other benzyl esters substituted with electron-withdrawing groups were specific for A3 receptors with nanomolar K(i) values and selectivity as high as 37000-fold. A functionalized congener bearing an [(aminoethyl)amino]carbonyl group was also prepared as an intermediate in the synthesis of biologically active conjugates.
