956296-81-4

Usage

Uses

Used in Chemical Synthesis:
2-(4-methoxyphenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid is used as an intermediate in the synthesis of near-IR fluorescent dyes for various applications, including bioimaging, diagnostics, and therapeutics. Its unique structure allows for the development of dyes with specific properties, such as high photostability, strong absorption, and emission in the near-IR region, which is advantageous for minimizing background interference and increasing tissue penetration.
Used in Bioimaging Applications:
In the field of bioimaging, 2-(4-methoxyphenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid is used as a precursor for the development of near-IR fluorescent probes. These probes enable the visualization of biological processes and structures with high spatial and temporal resolution, as well as reduced phototoxicity and autofluorescence compared to visible light dyes.
Used in Diagnostics:
2-(4-methoxyphenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid is utilized in the creation of near-IR fluorescent contrast agents for medical imaging techniques, such as fluorescence imaging and photoacoustic imaging. These agents can enhance the contrast between healthy and diseased tissues, aiding in the early detection and diagnosis of various conditions, including cancer.
Used in Therapeutics:
In the therapeutics industry, 2-(4-methoxyphenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid is employed as a building block for the development of photodynamic therapy (PDT) agents. These agents can generate reactive oxygen species upon exposure to near-IR light, leading to the selective destruction of cancer cells and other diseased tissues while minimizing damage to surrounding healthy cells.
Overall, 2-(4-methoxyphenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid is a versatile compound with significant potential in various industries, particularly in the development of near-IR fluorescent dyes and their applications in bioimaging, diagnostics, and therapeutics.

Upstream product

• 956296-80-3 2-(4-methoxyphenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 956296-79-0 ethyl 2-azido-3-[5-(4-methoxyphenyl)-furan-2-yl]acrylate 
• 34070-33-2 5-(4-methoxyphenyl)furan-2-carbaldehyde 
• 5720-07-0 4-methoxyphenylboronic acid 

Downstream Products

• 956296-83-6 2-(4-methoxyphenyl)-4H-furo[3,2-b]pyrrole 
• 1006592-41-1 2-(4-methoxyphenyl)-4H-furo[3,2-b]pyrrole-5-carbaldehyde 
• 956296-91-6 C₂₈H₁₉F₃N₂O₄ 

Relevant academic research and scientific papers

Small molecule near-infrared boron dipyrromethene donors for organic tandem solar cells

Three furan fused boron dipyrromethenes (BODIPYs) with a CF3 group on the meso-carbon are synthesized as near-infrared absorbing materials for vacuum processable organic solar cells. The best single junction device reaches a short-circuit curre

RESIN COMPOSITION AND MOLDED ARTICLE

The invention contains a resin and a near infrared fluorescent material which is one type or two or more types of compounds selected from General Formulas (I1) to (I4) and has a maximum fluorescence wavelength of 650 nm or longer. In Formulas, Ra and Rb, Rc and Rd, Rh and Ri, and Rj and Rk form rings together with the nitrogen atom to which Ra, Rc, Rh, and Rj are bonded; Re and Rf represent a halogen atom or an oxygen atom; each of Rl, Rm, Rn, and Ro independently represents a halogen atom, a C1-20 alkyl group, a C1-20 alkoxy group, an aryl group, or a heteroaryl group; Rg, Rr, and Rs represent a hydrogen atom or an electron withdrawing group; and each of Rp and Rq independently represents a hydrogen atom, a halogen atom, a C1-20 alkyl group, a C1-20 alkoxy group, an aryl group, or a heteroaryl group.

Singlet oxygen generation by novel NIR BODIPY dyes

Five novel near-infrared BODIPY dyes were prepared for improved singlet oxygen generation using thiophene and bromine. Theoretical, optical, photostable, and singlet oxygen generation characteristics of these dyes were assessed. Predicted excitation energ

FLUORESCENT COMPOUND AND LABELING AGENT COMPRISING THE SAME

A novel fluorescent compound having a high light fastness, high fluorescence quantum yield and sharp absorption spectrum, which emits fluorescence having a wavelength in long wavelength region, as well as its use as a labeling agent, is disclosed. In Form

Bright, color-tunable fluorescent dyes in the Vis/NIR region: Establishment of new "tailor-made" multicolor fluorophores based on borondipyrromethene

A new series of high-performance fluorophores named Keio Fluors (KFL), which are based on borondipyrromethene (BODIPY), are reported. The KFL dyes cover a wide spectral range from the yellow (547 nm) to the near-infrared (NIR, 738 nm) region, and their emission wavelength could be easily and subtly controlled based on simple molecular modifications only, without losing their optical properties. This "tailor-made" synthetic strategy for tuning the emission wavelength enabled the creation of fourteen KFL dyes with well-controlled emission colors (yellow, orange, red, far-red, and NIR). Moreover, these KFL dyes also retain their excellent optical properties, such as spectral bands sharper than quantum dots, high extinction coefficients (140000-316000 M-1 cm-1), and high quantum yields (0.56-0.98), without any critical solvent polarity dependent decrease of their brightness. These advantageous characteristics make the KFL dyes potentially useful as new candidates of fluorescent standard dyes to substitute or to complement existing long-wavelength fluorescent dyes, such as cyanines, oxazines, rhodamines, or other BODIPY dyes.

Bright, color-tunable fluorescent dyes in the visible-near-infrared region

The newly synthesized Keio Fluors, which are based on boron-dipyrromethene (BDP), have excellent and useful optical properties: vivid colors and sharp emission in the visible-near-infrared region (583-738 nm), high quantum yields (Φ: 0.56-0.98), high exti