Configuration of the 5′-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides

DOI: 10.1021/jm101207e

Source and publish data:

Journal of Medicinal Chemistry p. 8309 - 8318 (2010)

Update date:2022-08-05

Topics:

Authors:

Seth, Punit P.

Allerson, Charles R.

Siwkowski, Andrew

Vasquez, Guillermo

Berdeja, Andres

Migawa, Michael T.

Gaus, Hans

Prakash, Thazha P.

Bhat, Balkrishen

Swayze, Eric E.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm101207e

As part of a program aimed at exploring the structure- activity relationships of 2′,4′-bridged nucleic acid (BNA) containing antisense oligonucleotides (ASOs), we report the synthesis and biophysical and biological properties of R- and S-5′-Me LNA modifie

Full text of DOI:10.1021/jm101207e

Products guided by the article

Product name:(1R,3R,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(4-N-benzoyl-cytosin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Cas No:956485-03-3

R&D Labs maybe for 956485-03-3

Zhejiang Genebest Pharmaceutical Co.,Ltd.

Contact:0086-571-63532866

Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Tianjin Hedong Red Cliff Chemical Reagent Factory

Contact:+86-022-84780548

Address:Li Ming Zhuang Gong Ye Yuan,Dongli District,Tianjin,China
BrightGene Bio-Medical Technology Co., Ltd.

website:https://en.bright-gene.com/

Contact:+86-512-62551801

Address:Building C25 - C31, No. 218 Xinghu Road, Suzhou Industrial Park, Suzhou, Jiangsu, China.
HaiNan Periwinkle Pharmaceutical Co.,Ltd.

website:http://www.cchpharm.com/en/index.html

Contact:020-82208978

Address:Gongye road,Wuzhishan city,HaiNan province
Suzhou Time-chem Technologies Co., Ltd.

Contact:0512-63983931/68086856

Address:No. 1326 of Binhe Road, New District, Suzhou, Jiangsu, P. R. China

Relevant to this article

Doi:10.1021/jm00342a011
(1963)
Doi:10.1007/BF00900286
(1963)
Studies on spasmolytics. II. Synthesis and anticholinergic activities of 4-acyloxy-1-alkyl-1-(1,3-dioxolan-4-ylmethyl)piperidinium compounds

Doi:10.1248/cpb.32.977
(1984)
Doi:10.1021/jo01068a050
(1961)
Doi:10.1002/hlca.19620450339
(1962)
Synthesis of 6-substituted 7-carbapurine 2',3'-dideoxynucleosides: Solid-liquid phase-transfer glycosylation of 4-chloropyrrolo[2,3-d]pyrimidine and deoxygenation of its 2'-deoxyribofuranoside

Doi:10.1055/s-1988-27667
(1988)

Article Doi