95652-80-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-methoxynicotinaldehyde is used as an intermediate in the synthesis of various drugs, contributing to the development of new pharmaceutical compounds.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Chloro-6-methoxynicotinaldehyde is used as a building block in the production of insecticides and herbicides, helping to create effective pest control solutions for agricultural applications.

InChI:InChI=1/C7H6ClNO2/c1-11-6-3-2-5(4-10)7(8)9-6/h2-4H,1H3

Upstream product

• 124-41-4 sodium methylate 
• 72648-12-5 2-chloro-3-(trichloromethyl)-pyridine 
• 40381-90-6 2,6-dichloro-3-pyridinecarbonitrile 
• 67-56-1 methanol 

Downstream Products

• 1585241-75-3 tert-butyl 3-((2S,3S)-5-(tert-butoxy)-3-(2-((4-methoxybenzyl)oxy)ethyl)-1-nitro-4,5-dioxopentan-2-yl)-6-methoxypicolinate 
• 1585241-87-7 1-benzyl 2-(tert-butyl) (2R,3S,4S)-4-(2-(tert-butoxycarbonyl)-6-methoxypyridin-3-yl)-3-(2-((4-methoxybenzyl)oxy)ethyl)pyrrolidine-1,2-carboxylate 
• 1585241-76-4 1-benzyl 2-(tert-butyl) (2S,3S,4S)-4-(2-(tert-butoxycarbonyl)-6-methoxypyridin-3-yl)-3-(2-((4-methoxybenzyl)oxy)ethyl)pyrrolidine-1,2-carboxylate 
• 1585241-88-8 1-benzyl 2-(tert-butyl) (2S,3S,4S)-4-(2-(tert-butoxycarbonyl)-6-methoxypyridin-3-yl)-3-(2-hydroxyethyl)pyrrolidine-1,2-dicarboxylate 
• 1585241-77-5 2-((2R,3S,4S)-1-((benzyloxy)carbonyl)-2-(tert-butoxycarbonyl)-4-(2-(tert-butoxycarbonyl)-6-methoxypyridin-3-yl)-pyrrolidin-3-yl)acetic acid 
• 1585241-97-9 C₃₅H₄₀N₂O₁₀ 
• 1585241-99-1 C₂₉H₃₈N₂O₉ 
• 1357946-21-4 3-bromo-6-methoxy-1H-pyrazolo[3,4-b]pyridine 

Relevant academic research and scientific papers

Transformations of trichloromethyl groups during reactions of 3-trichloromethylpyridines with methoxide

When methoxide ion attacks an unsubstituted 2- or 6-position of a 3-trichloromethylpyridine, a hydrogen shift leads to a methoxy-substituted 3-dichloromethylpyridine. Further reaction of the dichloromethyl group with methoxide gives the corresponding acetal. This type of reaction has been applied to several chlorinated 3-trichloromethylpyridines and to 3- trichloromethylpyridine itself; a convenient synthesis of the latter is described.

ABNORMAL NUCLEOPHILIC SUBSTITUTION OF 3-TRICHLOROMETHYLPYRIDINES BY METHOXIDE

3-Trichloromethylpyridine and its α-chlorinated derivatives behave as ambident electrophilic substrates towards methoxide which attacks an α-position and the trichloromethyl group.