72648-12-5

Basic information

• Product Name: 2-CHLORO-3-TRICHLOROMETHYLPYRIDINE
• Synonyms: AKOS BBS-00001893;2-CHLORO-3-TRICHLOROMETHYLPYRIDINE
• CAS NO: 72648-12-5
• Molecular Formula: C₆H₃Cl₄N
• Molecular Weight: 230.91
• Mol File: 72648-12-5.mol

Chemical Properties

• Boiling Point: 291.5 °C at 760 mmHg
• Flash Point: 157.7 °C
• Appearance: /
• Density: 1.582 g/cm³
• Vapor Pressure: 0.0034mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-CHLORO-3-TRICHLOROMETHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-TRICHLOROMETHYLPYRIDINE(72648-12-5)
• EPA Substance Registry System: 2-CHLORO-3-TRICHLOROMETHYLPYRIDINE(72648-12-5)

Safety Data

• Hazardous Substances Data: 72648-12-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-3-TRICHLOROMETHYLPYRIDINE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
2-CHLORO-3-TRICHLOROMETHYLPYRIDINE is utilized as a precursor in the production of agrochemicals, particularly in the creation of pesticides and other crop protection products, due to its antimicrobial properties.
Used in Organic Synthesis:
2-CHLORO-3-TRICHLOROMETHYLPYRIDINE is employed as a building block in organic synthesis, enabling the construction of complex organic molecules for research and development purposes.
Used in Disinfectant Formulation:
Leveraging its potent antimicrobial properties, 2-CHLORO-3-TRICHLOROMETHYLPYRIDINE is used in the formulation of disinfectants for various applications, including medical, industrial, and household use, to ensure cleanliness and prevent the spread of infections.

InChI:InChI=1/C6H3Cl4N/c7-5-4(6(8,9)10)2-1-3-11-5/h1-3H

Upstream product

• 108-99-6 3-Methylpyridine 
• 609-71-2 2-hydroxy-3-carboxypyridine 

Downstream Products

• 2942-59-8 2-chloronicotinic acid 
• 58819-72-0 2,6-dimethoxypyridine-3-carboxaldehyde 
• 95652-80-5 2-chloro-6-methoxy-3-pyridine-carboxaldehyde 
• 121643-43-4 2-chloro-3-dichloromethyl-6-methoxypyridine 
• 95652-79-2 2-chloro-3-(dimethoxymethyl)-6-methoxypyridine 

Relevant articles and documents

Refining and purification method and drying treatment apparatus for 2-chloronicotinic acid

The invention discloses a refining and purification method and a drying treatment apparatus for 2-chloronicotinic acid. The method comprises the following steps: reacting 3-methylpyridine with chlorine to produce 2-chloro-3-trichloromethylpyridine; hydrolyzing 2-chloro-3-trichloromethylpyridine to obtain a 2-chloronicotinic acid reaction product; and purifying and drying the 2-chloronicotinic acidreaction product by using the apparatus. The apparatus is applicable to drying treatment of 2-chloronicotinic acid and has a simple structure. The refining and purification method for 2-chloronicotinic acid can greatly improve the quality and purity of a 2-chloronicotinic acid product.

A 2 - chloro -5 - nitrapyrin preparation method

The invention discloses a 2 - chloro - 5 - trichloromethyl pyridine method, comprises the following steps: (1) the 3 - methyl pyridine is mixed with a solvent, the vaporization of the drops in the vaporization vessel, then in order to inert gas as a carrier gas, to form raw material steam; (2) dry Cl respectively2 The raw material and the steam is sent to the quartz tube catalyst [...] generating vapor phase chlorination reaction, reaction material after the condensation, rectification to obtain 2 - chloro - 5 - trichloromethyl pyridine. The invention relates to a 2 - chloro - 5 - trichloromethyl pyridine method, with raw materials are easy, low cost, easy to operate, simple process and the like.

Synthesis method of 2-chloro-trichloromethyl pyridine

The invention discloses a synthesis method of 2-chloro-trichloromethyl pyridine. The synthesis method comprises following steps: (1) oxidation reactions: dropwise adding an oxidizing agent into 3-trichloromethyl pyridine, and carrying out oxidation reactions at a temperature of 70 to 80 DEG C in the presence of a catalyst to obtain 3-chloromethyl pyridine oxynitride; and (2) chlorination reactions: carrying out chlorination reactions between 3-chloromethyl pyridine oxynitride obtained in the step (1) and a chlorination agent at a temperature of 20 to 25 DEG C to obtain the target product 2-chloro-trichloromethyl pyridine; wherein the solvent is an organic solvent and an organic alkali is taken as an acid-binding agent in chlorination reactions. The synthesis method is simple, the reactionconditions are mild, the yield is high, and the product purity can reach 95% or more.

PhPOCl2as a potent catalyst for chlorination reaction of phenols with PCl5

Phenols are easily converted to the corresponding aryl chlorides by using phosphorus pentachloride (PCl5) and a catalytic amount of phenylphosphonic dichloride (PhPOCl2), which is a new efficient method for synthesis of aryl chloride in good yields.

Vapor phase catalytic chlorination of ?-picoline

2-Chloro-5-trichloromethylpyridine is obtained by chlorinating β-picoline in the vapor phase using a Mordenite zeolite or a supported palladium catalyst.