95766-36-2Relevant academic research and scientific papers
Direct Synthesis of Free α-Amino Acids by Telescoping Three-Step Process from 1,2-Diols
Inada, Haruki,Shibuya, Masatoshi,Yamamoto, Yoshihiko
supporting information, p. 709 - 713 (2019/01/25)
A practical telescoping three-step process for the syntheses of α-amino acids from the corresponding 1,2-diols has been developed. This process enables the direct synthesis of free α-amino acids without any protection/deprotection step. This method was also effective for the preparation of a 15N-labeled α-amino acid. 1,2-Diols bearing α,β-unsaturated ester moieties afforded bicyclic α-amino acids through intramolecular [3 + 2] cycloadditions. A preliminary study suggests that the resultant α-amino acids are resolvable by aminoacylases with almost complete selectivity.
Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The α-methyl-trans-lactam template
Borthwick,Angier,Crame,Exall,Haley,Hart,Mason,Pennell,Weingarten
, p. 4452 - 4464 (2007/10/03)
Mechanism-based inhibitors of human cytomegalovirus (HCMV) protease have been designed based on the pyrrolidine-5,5-trans-lactam ring system. New routes to the β-methyl-, desmethyl-, and α-methyl-pyrrolidine-5,5-trans-lactam templates have been developed
Synthesis and biological activities of two ACTH analogues containing L norarginine in position 8
Van Nispen,Tesser,Nivard
, p. 193 - 202 (2007/10/06)
2 new ACTH-analogues, an octadecapetide amide and a tetracosapeptide containing the lower homologue of arginine (norarginine) in position 8, have been synthesized by the generally accepted method. Special attention was paid to the synthesis of the required tetrapeptide representing the 7-10 sequence, which was obtained either by direct introduction of L-nitronorarginine or by amidination of the γ-amino function in a protected peptide containing α, γ diaminobutyric acid. Biological activity determination showed that the shortening of the arginine side chain in position 8 results in the formation of active ACTH-analogues.
