958219-45-9

Usage

Chemical class

Phenylacetic acids

Physical state

White solid at room temperature

Solubility

Sparingly soluble in water

Use in industry

Building block for the synthesis of various drugs and pharmaceutical intermediates

Biological activities

Potential anti-inflammatory and analgesic properties

Unique properties

Presence of thiophene and phenyl moieties in its structure, making it a valuable molecule for research and drug development.

Upstream product

• 154191-77-2 methyl <2-(2-thienyl)phenyl>acetate 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 18698-97-0 ortho-bromophenylacetic acid 
• 956229-86-0 methyl 2-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate 

Relevant academic research and scientific papers

Identification of two novel thiophene analogues as inducers of autophagy mediated cell death in breast cancer cells

Natural compounds isolated from different medicinal plants remain one of the major resources of anticancer drugs due to their enormous chemical diversity. Studies suggested therapeutic potential for various tanshinones, key bioactive lipophilic compounds

PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS

The invention encompasses novel compounds of Formula or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmacuetical compositions are also encompassed