154191-77-2Relevant academic research and scientific papers
Identification of two novel thiophene analogues as inducers of autophagy mediated cell death in breast cancer cells
Gain, Chandrima,Sarkar, Aparna,Bural, Shrea,Rakshit, Moumita,Banerjee, Jeet,Dey, Ankita,Biswas, Nabendu,Kar, Gandhi K.,Saha, Abhik
, (2021/03/29)
Natural compounds isolated from different medicinal plants remain one of the major resources of anticancer drugs due to their enormous chemical diversity. Studies suggested therapeutic potential for various tanshinones, key bioactive lipophilic compounds
PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS
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, (2008/06/13)
The invention encompasses novel compounds of Formula or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmacuetical compositions are also encompassed
Potentially Aromatic Thiophenium Ylides. V. Reactions of Ethoxycarbonyl- (and Methoxycarbonyl)-2-(2-thienyl)phenylcarbene
Solbakken, Magne,Skramstad, Jan
, p. 1214 - 1220 (2007/10/02)
In an attempt to make thiophenium ylides in which the ylide bond is part of a five-membered ring annulated to the α-side of the thiophene moiety, two alkoxycarbonyl substituted 2-(2-thienyl)phenylcarbenes have been made, with and without chlorine substituents in the remaining thiophene positions.With rhodium acetate as a catalyst the carbene without chlorines cyclized to the 3-position of the thiophene to give a fluorene analogue, whereas no cyclization was detected when the 3-position was blocked.
