95891-67-1

Upstream product

• 77903-44-7 t-2-Phenyl-c-2-(trimethylsiloxy)-r-1-cyclopropancarbonsaeure-methylester 
• 75-77-4 chloro-trimethyl-silane 
• 25333-24-8 3-benzoylpropionic acid methyl ester 

Downstream Products

• 85515-55-5 methyl 4-oxo-4-phenyl-3-iodobutanoate 
• 95891-82-0 (5S,6R)-5-Benzoyl-6-phenyl-tetrahydro-pyran-2-one 
• 95891-81-9 (5S,6S)-5-Benzoyl-6-phenyl-tetrahydro-pyran-2-one 
• 95891-83-1 5-Benzoyl-1-oxa-spiro[5.5]undecan-2-one 
• 95891-80-8 5-Benzoyl-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

β-Diazocarbonyl Compounds: Synthesis and their Rh(II)-Catalyzed 1,3 C?H Insertions

Herein, we describe the first electrophilic diazomethylation of ketone silyl enol ethers with diazomethyl-substituted hypervalent iodine reagents that gives access to unusual β-diazocarbonyl compounds. The potential of this unexplored class of diazo compounds for the development of new reactions was demonstrated by the discovery of a rare Rh-catalyzed intramolecular 1,3 C?H carbene insertion that led to complex cyclopropanes with excellent stereocontrol.

LOW TEMPERATURE EQUILIBRATION OF CYCLOPROPANES BY LEWIS ACID CATALYSIS

Under the influence of Lewis acids the cis/trans-equilibration of methyl 2-trimethyl-siloxy cyclopropanecarboxylates occurs even at -78 deg C.It involves the heterolytic cleavage of a C-C bond and seems to be governed by steric effects.