959-05-7

Usage

Chemical compound

6-chloro-3-(4-chlorophenyl)-3,4-dihydroquinazoline

Class

Quinazoline

Substitutions

Chloro at 6 position, 4-chlorophenyl at 3 position

Pharmacological properties

Potential

Applications

Development of pharmaceutical drugs

Interest for research

Chemical structure and potential medical use

Upstream product

• 64-18-6 formic acid 
• 123333-40-4 N-(2-amino-5-chloro-benzyl)-4-chloro-aniline 
• 50-00-0 formaldehyd 
• 106-47-8 4-chloro-aniline 
• 864131-95-3 N,N'-diphenylformamidine 
• 7647-01-0 hydrogenchloride 
• 122-51-0 orthoformic acid triethyl ester 
• 20265-96-7 p-chloroaniline hydrochloride 
• 64-17-5 ethanol 
• 53654-69-6 N,N'-bis-(4-chloro-phenyl)-methanediyldiamine 

Downstream Products

• 127662-21-9 3-phenyl-1,2,3,4-tetrahydroquinazoline 
• 33900-94-6 6-chloro-3-(4-chlorophenyl)quinazolin-4(3H)-one 

Relevant academic research and scientific papers

Mild environment-friendly oxidative debenzylation of N-benzylanilines using DMSO as an oxidant

Oxidative debenzylation of N-benzyl aromatic amines using DMSO as a non-toxic oxidant and catalyzed by TsOH gave Nphenylimines, which were spontaneously hydrolyzed to form anilines and benzaldehydes in good yields. This reaction employs mild, metal-free conditions. The conditions are also suitable for the debenzylation of benzylphenylethers.

Two isolated intermediates of the Tr?ger's base: synthesis and mechanism

By controlling the amount of catalyst 1-methyl-3-(2-(sulfooxy)ethyl)-1H-imidazol-3-ium chloride, two new intermediates of Tr?ger's bases (11, 1,6-dimethyl-3-(4-methylphenyl)-1,4-dihydroquinazolin-3-ium tetrafluoroborate and 12, 8-methyl-2,5-bis-(4-methylp

An efficient synthesis of quinazoline derivatives with the aid of low-valent titanium reagent

Quinazolin-4(3H)-ones, 1,2-dihydroquinazolin-4(3H)-ones, 3,4-dihydroquinazolines, imidazo[1,2-c]-quinazolines and 5,6-dihydroimidazo[1,2- c]quinazolines were synthesized by the novel reductive reaction of nitro group, N-H bond and ortho-ester, aldehydes o

Synthesis of quinazolines and imidazo[1,2-c]quinazolines with the aid of a low-valent titanium reagent

A short and facile synthesis of a series of quinazolines and imidazo[1,2-c]quinazolines was accomplished in good yields via the novel reductive cyclization of 2-nitrobenzyl amines or 2-(2-nitrophenyl)imidazoles with ortho-ester, aldehydes or ketones promoted by TiCl4/Zn system. The structures were established by spectroscopic data and confirmed by X-ray analysis.