95956-56-2

Upstream product

• 637-69-4 4-Methoxystyrene 
• 43192-31-0 2-bromo-4-methoxybenzaldehyde 
• 5159-86-4 methyl tri-(4-methoxyphenyl)acrylate 
• 5042-61-5 2,3,3-tris-(4-methoxy-phenyl)-acrylic acid 
• 25354-46-5 1-bromo-1,2,2-tris(p-methoxyphenyl)ethene 
• 824-98-6 m-methoxybenzyl chloride 
• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 
• 114095-36-2 1,2-bis(4-methoxyphenyl)-3-(3-methoxyphenyl)-1-propanone 

Downstream Products

• 114095-39-5 2,3-bis(4-hydroxyphenyl)-6-hydroxyindene 
• 114095-38-4 6-methoxy-2,3-bis(4-methoxyphenyl)-1H-inden-1-one 
• 96366-70-0 6-Methoxy-2,3-bis-(4-methoxy-phenyl)-indan 
• 97432-74-1 6-Methoxy-2,3-bis-(4-methoxy-phenyl)-1-benzyliden-inden 
• 114095-35-1 2,3-bis(4-hydroxyphenyl)-6-hydroxyindenone 

Relevant academic research and scientific papers

Gold Catalysis of Non-Conjugated Haloacetylenes

Gold-catalyzed reactions of conjugated haloacetylenes are well known and usually result in the formation of addition or dimerization products. Herein, we report a gold-catalyzed reaction of non-conjugated haloacetylenes, which leads exclusively to the hal

Selective Divergent Synthesis of Indanols, Indanones, and Indenes via Acid-Mediated Cyclization of (Z)- and (E)-(2-Stilbenyl)methanols and Its Application for the Synthesis of Paucifloral F Derivatives

Starting from bromo/iodobenzaldehyde derivatives, the corresponding (Z)- and (E)-(2-stilbenyl)methanols could be prepared in 2-5 steps via Pd-catalyzed cross-coupling reactions (Sonogashira and Heck reactions) followed by aryllithium/aryl Grignard addition. For the (E)-stilbenes, subsequent acid-mediated cyclization using p-TsOH immobilized on silica (PTS-Si) at low temperatures furnished the 2,3-trans-1-indanols with complete stereocontrol at the C2-C3. Further oxidization of the alcohol provided the indanones, which are structurally related to the natural product paucifloral F. At higher temperatures, 1,2- and 2,3-disubstituted indenes could be selectively prepared in good to excellent yields. On the other hand, the (Z)-stilbenes, under similar conditions (PTS-Si), did not give the indanols; only the 1,2-disubstituted indenes could be obtained. To gain further insights into the stereochemistry at C2-C3 for the (Z)-stilbenes, hydride or azide was employed as a nucleophile; the corresponding indane products were obtained with the cis stereochemistry at the C2-C3. Thus, the (Z)- or (E)-olefin geometry of the substrate directed the stereoselective indanyl cyclization to furnish the cis or trans at the C2-C3 ring junction, respectively, while reaction conditions controlled the selectivity of the product types.

2,3-Diarylindenes and 2,3-diarylindenones: Synthesis, molecular structure, photochemistry, estrogen receptor binding affinity, and comparisons with related triarylethylenes

Two 2,3-diphenylindene and -indenone systems, with potential fluorescent and photofluorogenic properties, were prepared and studied as ligands for the estrogen receptor. The indene systems were prepared by Friedel-Crafts cyclization of appropriate α-benzy