960009-35-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-5-[(4-methyl-1-piperazinyl)sulfonyl]benzoic acid is used as an impurity in the production of Sildenafil Citrate, which is a medication used for treating erectile dysfunction and pulmonary arterial hypertension. Its presence as an impurity is important for quality control and ensuring the safety and efficacy of the final product.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 17243-13-9 5-chlorosulfonyl-2-hydroxybenzoic acid 

Downstream Products

• 960009-37-4 5-[2-ethoxycarbonyloxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 1093065-15-6 5-[2-ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine 
• 1363693-50-8 5-[2-hydroxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine 
• 1363693-47-3 5-[2-ethoxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-6-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 139755-83-2 viagra 
• 960009-36-3 4-[2-hydroxy-5-(4-methylpiperazine-1-ylsulphonyl)benzamido]-1-methyl-3-n-propyl-1H-pyrazole-5-carboxamide 
• 200575-15-1 4-[2-ethoxy-5-(4-methyl-1-piperazinylsulphonyl)benzamido]-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 

Relevant academic research and scientific papers

NOVEL PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE

Disclosed herein the process for producing 5-[2-ethoxy-5-(4-methyl)piperazine-l-yl- sulfonyl)phenyl]- 1 -methyl-3-n-propyl- 1 ,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one or its salt thereof employing novel intermediate.

Polymer-supported reagents for multi-step organic synthesis: Application to the synthesis of sildenafil

Sildenafil 1 (Viagra(TM)), a well known and commercially important pharmaceutical drug, has been prepared using polymer-supported reagents in a multi-step, convergent process resulting in a clean and efficient preparation without the need for conventional purification methods. (C) 2000 Elsevier Science Ltd.