1093065-15-6Relevant articles and documents
Synthesis of Sildenafil citrate and process related impurities
Kumar, Indukuri V.S.,Ramanjaneyulu, Gorantla S.,Bindu, Vurimindi H.
, p. 668 - 673 (2012/06/01)
Synthesis of Sildenafil by the O-alkylation of 5-[2-hydroxy-5-(4- methylpiperazin-1-ylsulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H- pyrazolo-[4,3-d]pyrimidin-7-one 8 proved difficult because concomitant alkylation of the pyrimidine moity also occurred. The selective O-alkylation was carried by DCC assisted decarboxilative etherification of the carbonate 9.