960009-36-3

Usage

Molecular Structure

Long and complex

Functional Groups

Benzamide
Hydroxyl
Methyl
Propyl
Piperazine-1-ylsulphonyl

Derivative

Carboxamide derivative of pyrazole

Application

Used in pharmaceutical research

Potential Uses

Drug development for various medical conditions

Research Status

Further research needed to understand its properties and potential applications

Upstream product

• 139756-02-8 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 
• 960009-35-2 2-hydroxy-5-(4-methylpiperazin-1-ylsulphonyl)benzoic acid 

Downstream Products

• 139755-83-2 viagra 
• 1363693-50-8 5-[2-hydroxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine 
• 1093065-15-6 5-[2-ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine 
• 1363693-47-3 5-[2-ethoxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-6-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 960009-37-4 5-[2-ethoxycarbonyloxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 

Relevant academic research and scientific papers

Synthesis of Sildenafil citrate and process related impurities

Synthesis of Sildenafil by the O-alkylation of 5-[2-hydroxy-5-(4- methylpiperazin-1-ylsulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H- pyrazolo-[4,3-d]pyrimidin-7-one 8 proved difficult because concomitant alkylation of the pyrimidine moity also occurred. The selective O-alkylation was carried by DCC assisted decarboxilative etherification of the carbonate 9.

NOVEL PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE

Disclosed herein the process for producing 5-[2-ethoxy-5-(4-methyl)piperazine-l-yl- sulfonyl)phenyl]- 1 -methyl-3-n-propyl- 1 ,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one or its salt thereof employing novel intermediate.