960298-00-4

Basic information

• Product Name: 2-(Benzyloxy)-4-bromopyridine
• Synonyms: 2-(Benzyloxy)-4-bromopyridine
• CAS NO: 960298-00-4
• Molecular Formula: C₁₂H₁₀BrNO
• Molecular Weight: 264.1179
• Mol File: 960298-00-4.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2-(Benzyloxy)-4-bromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Benzyloxy)-4-bromopyridine(960298-00-4)
• EPA Substance Registry System: 2-(Benzyloxy)-4-bromopyridine(960298-00-4)

Safety Data

• Hazardous Substances Data: 960298-00-4(Hazardous Substances Data)

Usage

General Description

2-(Benzyloxy)-4-bromopyridine is a chemical compound with the molecular formula C12H10BrNO. It is a pyridine derivative with a benzyl ether group and a bromine atom attached to the 4-position of the pyridine ring. 2-(Benzyloxy)-4-bromopyridine is commonly used as a building block in organic synthesis and medicinal chemistry, and it has potential applications in the development of pharmaceuticals and agrochemicals. Its unique structure and functional groups make it a valuable intermediate for the synthesis of diverse compounds with biological activity. Additionally, the bromine atom in its structure can be exploited for further functionalization through various chemical reactions, making it a versatile and useful chemical in chemical research and development.

Upstream product

• 100-39-0 benzyl bromide 
• 128071-98-7 4-bromo-2-fluoropyridine 
• 100-51-6 benzyl alcohol 
• 36953-37-4 4-bromo-2(1H)-pyridinone 
• 73583-37-6 2-chloro-4-bromopyridine 
• 1214900-01-2 2-(benzyloxy)pyridin-4-amine 
• 14432-12-3 4-Amino-2-chloropyridine 

Downstream Products

• 1423175-51-2 2-(benzyloxy)-4-(2-fluoro-4-methyl-5-((2,2,2-trifluoroethyl)thio)phenyl)pyridine 
• 1423175-52-3 2-(benzyloxy)-4-(2-fluoro-4-methyl-5-((2,2,2-trifluoroethyl)sulfinyl)phenyl)pyridine 
• 36953-37-4 4-bromo-2(1H)-pyridinone 

Relevant articles and documents

GPR40 AGONISTS

This disclosure is directed, at least in part, to GPR40 agonists useful for the treatment of conditions or disorders involving the gut-brain axis. In some embodiments, the GPR40 agonists are gut-restricted compounds. In some embodiments, the GPR40 agonists are full agonists or partial agonists. In some embodiments, the condition or disorder is a metabolic disorder, such as diabetes, obesity, nonalcoholic steatohepatitis (NASH), or a nutritional disorder such as short bowel syndrome.

Mild and Regioselective N-Alkylation of 2-Pyridones in Water

A mild and regioselective N-alkylation reaction of 2-pyridones in water has been developed. Tween 20 (2% w/w) was added to create a micellar system for improved solubility of starting materials, which leads to enhanced reaction rates. The protocol demonstrated a wide substrate scope with good isolated yields (40-94%) for all of the 24 examples evaluated. High regioselectivity favoring N-alkylation over O-alkylation was observed for benzyl halides (>5:1), primary alkyl halides (>6:1), and bulky and less reactive secondary alkyl halides (>2.4:1).

PESTICIDE

A novel pesticide is provided. The present invention provides a compound represented by the formula (I) or its salt: wherein Q is phenyl or pyridyl which may be substituted; W is an oxygen atom or S(O)m; each of A1 to A5 is -C(R5)= or a nitrogen atom, provided that among A1 to A5, the number of groups which may be nitrogen atoms, is from 0 to 2; each of B1 to B4 is a hydrogen atom, a halogen atom, alkyl or haloalkyl; each of R1 and R2 is a hydrogen atom, a halogen atom, alkyl, haloalkyl, alkoxy, haloalkoxy or cyano; and R3 is alkyl or haloalkyl.