96034-57-0

Basic information

• Product Name: TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE
• Synonyms: TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE;P-NITRO BENZYL 2(S) CARBOXY TRANS 4(R) HYDROXY L P;(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic Acid 1-(4-Nitrobenzyl) Ester;1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-[(4-nitrophenyl)Methyl] ester;(2S,4R)-1-(4-Nitrobenzyloxycarbonyl)-4-hydroxyproline;1,2-Pyrrolidinedicarboxylicacid, 4-hydroxy-, 1-[(4-nitrophenyl)methyl] ester, (2S,4R)-;(2S,4R)-1-((4-NITROBENZYLOXY)CARBONYL)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;(2S,4R)-4-Hydroxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine-2-carboxylic acid
• CAS NO: 96034-57-0
• Molecular Formula: C₁₃H₁₄N₂O₇
• Molecular Weight: 310.25900
• EINECS: 1533716-785-6
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 96034-57-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 182-183℃
• Boiling Point: 578.308 °C at 760 mmHg
• Flash Point: 303.55 °C
• Appearance: /Solid
• Density: 1.557
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol
• PKA: 3.69±0.40(Predicted)
• CAS DataBase Reference: TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE(96034-57-0)
• EPA Substance Registry System: TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE(96034-57-0)

Safety Data

• Hazardous Substances Data: 96034-57-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Intermediate in the production of Meropenem.

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 619-73-8 4-nitrobenzyl chloride 

Downstream Products

• 132984-58-8 trans-4-chloroacetoxy-1-(4-nitro-benzyloxycarbonyl)-L-proline 
• 138324-82-0 (2S,4R)-4-mesyloxy-1-(p-nitrobenzyloxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester 
• 96035-08-4 (2S,4R)-2-carbamoyl-4-mesyloxy-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 230964-57-5 p-nitrobenzyl (1R,5S,6S)-6-<(1R)-1-hydroxyethyl>-2-<(5S,7S)-2,2,3-trimethyl-4-oxo-1,3-diazabicyclo<3.3.0>octan-7-ylthio>-1-methylcarbapen-2-em-3-carboxylate 
• 188578-76-9 2-Phenyl-2,5-diazabicyclo[2.2.1]heptan-3-one 
• 188578-75-8 2-Phenyl-5-(p-nitrobenzyloxycarbonyl)-2,5-diazabicyclo[2.2.1]heptan-3-one 
• 188578-77-0 (2S,4R)-N-Benzyl-4-hydroxy-1-(p-nitrobenzyloxycarbonyl)prolinamide 
• 151071-99-7 (2S,4R)-1-p-nitrobenzyloxycarbonyl-4-methanesulfonyloxy-2-pyrrolidinethiocarboxylic acid 
• 151072-00-3 (2S,4S)-5-p-nitrobenzyloxycarbonyl-2-thia-5-azabicyclo<2.2.1>heptan-3-one 

Relevant articles and documents

DERIVATIZATION OF BETA-LACTAM ANTIBIOTICS AS CALIBRATORS/ISTD IN MASSSPEC MEASUREMENTS

The invention relates to a complex comprising an antibiotic substance and a nucleophilic derivatization reagent, compositions comprising the complex, kits comprising complex or composition, as well as uses of the complex or composition.

A luer Ertapenem, luer he lateral chain and its preparation method

The invention discloses ertapenem and ertapenem side chains, as well as preparation methods of ertapenem and ertapenem side chains. L-hydroxyproline is protected by p-nitrobenzyl ester to obtain (2S,4R)-4-hydroxyl-1-(((4-Nitrobenzformyl)-oxyl)caboyl)pyrrolidine-2-carboxylic acid; then 4-nitro(1S,4S)-3-oxo-2-thia-5-azabicyclo[2.2.1]heptan-5-carboxylic anhydride can be obtained, and reacts with m-aminobenzoic acid p-nitrobenzyl ester to obtain ertapenem side chain III; and the ertapenem can be synthesized through two-step chemical reaction of condensation and deprotection to the ertapenem side chain III and a raw material MAP. An ertapenem side chain I (10), an ertapenem side chain II (13) and the ertapenem side chain III (2) which are prevailing in the market can be synthesized through simple steps, without the need of ultralow temperature, industrialization is easy, and the product purity is high, and the operation is simple and convenient.

AN IMPROVED PROCESS FOR THE PREPARATION OF MEROPENEM

The present invention provides an improved process for the preparation of methyl carbapenem derivative of formula (I) or its pharmaceutically acceptable salts or hydrates thereof in a pure form.