96129-66-7Relevant academic research and scientific papers
PROTEIN KINASE INHIBITORS AND USES THEREOF FOR THE TREATMENT OF DISEASES AND CONDITIONS
-
Paragraph 0151-0152, (2020/11/30)
Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2) and/or receptor interacting kinase 3 (RIPK3). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 or RIPK3 could provide therapeutic benefit. Compounds that function as RIPK3 inhibitors provide therapeutic benefit in the treatment of inflammatory and degenerative conditions.
PYRIDO[2,3-D]PYRIMIDIN-7ONES AND RELATED COMPOUNDS AS INHIBITORS OF PROTEIN KINASES
-
Paragraph 0090-0092; 0010, (2018/12/13)
Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds having the structures below (I) are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.
ANTI-HCMV COMPOSITIONS AND METHODS
-
Page/Page column 92; 94; 98; 99, (2016/06/06)
This document relates to compounds useful as agents for preventing or treating human cytomegalovirus (HCMV) infections.
2- and 2,5-substituted phenylketoenols
-
Page column 80, (2010/01/31)
The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I) in which Het represents one of the groups ?in which A, B, D, G, X and Z are each as defined in the description, to a plurality of processes and intermediates for their preparation, and to their use as pesticides.
Solution and Flash Vacuum Pyrolysis of Some 2,6-Disubstituted β-Phenethylsulfonyl Azides and of β-Styrenesulfonyl Azide
Abramovitch, Rudolph A.,Kress, Albert O.,Pillay, Kutten S.,Thompson, W. Marshall
, p. 2066 - 2073 (2007/10/02)
Solution thermolysis of 2,6-dichloro-β-phenethyl- and 2,6-dimethyl-β-phenethylsulfonyl azide leads to the formation of the corresponding 5,8-disubstituted 3,4-dihydro-2,1-benzothiazine 2,2-dioxides resulting from a 1,2-chlorine and -methyl shift, respectively, in the intermediates.No insertion into the phenethyl side chain, or into the side-chain methyl group in the 2,6-dimethyl case, was detected.Attempted cyclization of ethene-sulfonanilides to 2,1-benzothiazine 2,2-dioxide failed.The orientation of the dichlorosultam was established unambiguously by its FVP to 4,7-dichloroindoline and by the synthesis of an authentic sample.Solution thermolysis of β-styrenesulfonyl azide gave only hydrogen abstraction (32) and solvent insertion (33) products, but FVP gave indole, phenylacetonitrile, and phenylacetylene.
