96169-02-7

Usage

Uses

Used in Pharmaceutical Industry:
1-Propanone, 1-[2,4-dihydroxy-6-methoxy-3-(3-methylbutyl)phenyl]-3-(4-hydroxyphenyl)is used as a pharmaceutical agent for its antiproliferative and anti-inflammatory properties. 1-Propanone,
1-[2,4-dihydroxy-6-methoxy-3-(3-methylbutyl)phenyl]-3-(4-hydroxyphenyl
)has demonstrated improved antiproliferative activity against cancer cells, making it a potential candidate for the development of anticancer drugs. Additionally, its anti-inflammatory activity in human monocytic THP-1 cells suggests its potential use in treating inflammatory conditions.
Used in Drug Delivery Systems:
To enhance the therapeutic efficacy and bioavailability of 1-Propanone, 1-[2,4-dihydroxy-6-methoxy-3-(3-methylbutyl)phenyl]-3-(4-hydroxyphenyl)-, researchers are developing novel drug delivery systems. These systems aim to improve the compound's solubility, stability, and targeted delivery to specific cells or tissues, thereby maximizing its therapeutic potential while minimizing side effects.
Used in Cosmetic Industry:
Due to its unique structure and functional groups, 1-Propanone, 1-[2,4-dihydroxy-6-methoxy-3-(3-methylbutyl)phenyl]-3-(4-hydroxyphenyl)may also find applications in the cosmetic industry. Its potential use as an active ingredient in skincare products could be explored for its antioxidant, anti-inflammatory, and anti-aging properties, contributing to improved skin health and appearance.

Upstream product

• 91555-33-8 1-(2,6-dihydroxy-4-methoxyphenyl)-3-methylbutan-1-one 
• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 108-73-6 3,5-dihydroxyphenol 
• 90632-20-5 1-[6-hydroxy-2,4-bis(methoxymethoxy)-3-(3-methylbut-2-en-1-yl)phenyl]ethanone 
• 160624-22-6 1-{2,4-bis(methoxymethoxy)-6-[(3-methylbut-2-en-1-yl)oxy]phenyl}ethanone 
• 26103-97-9 phloroisovalerophenone 
• 569-83-5 xanthohumol 
• 91765-42-3 2-isopentyl-5-methoxy-resorcinol 
• 950186-11-5 3-(4-acetoxyphenyl)propanenitrile 

Relevant academic research and scientific papers

Xanthohumol, a polyphenol chalcone present in hops, activating nrf2 enzymes to confer protection against oxidative damage in pc12 cells

Xanthohumol (2a?2,4a?2,4-trihydroxy-6a?2-methoxy-3a?2-prenylchalcone, Xn), a polyphenol chalcone from hops (Humulus lupulus), has received increasing attention due to its multiple pharmacological activities. As an active component in beers, its presence has been suggested to be linked to the epidemiological observation of the beneficial effect of regular beer drinking. In this work, we synthesized Xn with a total yield of 5.0% in seven steps and studied its neuroprotective function against oxidative-stress-induced neuronal cell damage in the neuronlike rat pheochromocytoma cell line PC12. Xn displays moderate free-radical-scavenging capacity in vitro. More importantly, pretreatment of PC12 cells with Xn at submicromolar concentrations significantly upregulates a panel of phase II cytoprotective genes as well as the corresponding gene products, such as glutathione, heme oxygenase, NAD(P)H:quinone oxidoreductase, thioredoxin, and thioredoxin reductase. A mechanistic study indicates that the ?±,?2-unsaturated ketone structure in Xn and activation of the transcription factor Nrf2 are key determinants for the cytoprotection of Xn. Targeting the Nrf2 by Xn discloses a previously unrecognized mechanism underlying the biological action of Xn. Our results demonstrate that Xn is a novel small-molecule activator of Nrf2 in neuronal cells and suggest that Xn might be a potential candidate for the prevention of neurodegenerative disorders.

Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro

Prenylated flavonoids found in hops and beer, i.e., prenylchalcones and prenylflavanones, were examined for their ability to inhibit in vitro oxidation of human low-density lipoprotein (LDL). The oxidation of LDL was assessed by the formation of conjugate