962-06-1

Upstream product

• 10507-69-4 4-methoxybenzohydroxamic acid 
• 98-86-2 acetophenone 
• 2909-38-8 m-chlorophenyl isocyanate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 118509-12-9 (Z)-2-Benzoyl-N-(3-chloro-phenyl)-3-(2,4-dichloro-phenyl)-acrylamide 
• 118533-89-4 5-(2,4-Dichloro-phenyl)-1-(5,6-diphenyl-[1,2,4]triazin-3-yl)-3-phenyl-4,5-dihydro-1H-pyrazole-4-carboxylic acid (3-chloro-phenyl)-amide 
• 118509-16-3 (Z)-N-(3-Chloro-phenyl)-3-(2,4-dichloro-phenyl)-2-{[(5,6-diphenyl-[1,2,4]triazin-3-yl)-hydrazono]-phenyl-methyl}-acrylamide 
• 118509-07-2 (3-Chloro-phenyl)-[1-(5,6-diphenyl-[1,2,4]triazin-3-yl)-5-phenyl-1H-pyrazol-3-yl]-amine 

Relevant academic research and scientific papers

1,4,2-Dioxazol-5-ones as Isocyanate Equivalents: An Efficient Synthesis of 2-Quinolinones via β-Keto Amides

Under thermal conditions, 1,4,2-dioxazol-5-ones are known to undergo decarboxylation followed by Lossen's rearrangement to yield isocyanates. Described herein is the in situ trapping of the resulting isocyanates with carbon nucleophiles to synthesize β-keto amides. Furthermore, a general and mild method for the conversion of the resulting β-keto amides into quinolin-2-ones is reported.

Silver(I)-catalyzed tandem approach to β-oxo amides

A facile and efficient AgI-catalytic approach is reported for the first time to synthesize β-oxo amides from β-oxo esters a with broad substrate scope in good to excellent yields. Crossover and in situ NMR studies confirmed that the reaction occurred through a new pathway and not by the traditional condensation reaction. The key advantages of this method are the readily available starting materials, the air-stable reaction, the simple protocol, and the environmental friendliness. A new, catalytic approach to the synthesis of β-oxo amides from β-oxo esters with a broad substrate scope in good to excellent yields was developed. In situ NMR spectroscopy and crossover experiments confirmed the reaction mechanism.

Reaction of 3-Hydrazino-5,6-diphenyl-1,2,4-triazine with Unsymmetrical 1,3-Bicarbonyl Compounds : Synthesis of Some New 3-(3',5'-Disubstituted pyrazol-1'-yl)-5,6-diphenyl-1,2,4-triazines and Their Antimicrobial Activity

The reactions of 3-hydrazino-5,6-diphenyl-1,2,4-triazine (I) with unsymmetrical 1,3-bicarbonyl compounds such as α-cyanoacetophenone, benzoylacetanilide, anilino-α,β-unsaturated ketone, benzoylacetic acid hydrazide, N1-cyanoacetyl-N2-benzoylacetylhydrazine, N1-benzene-N2-benzoyl-acetylhydrazine, 1,1,1-trifluoroacetylacetone, 1,1,1,5,5,5-hexafluoropenta-2,4-dione and 1-benzoylacetone-2-oxime, have been studied in abs. ethanol, gl. acetic acid and ethanol-piperidine media.These reactions result in some new 3-(3',5'-disubstituted pyrazol-1'-yl)-5,6-diphenyl-1,2,4-triazines.Some of these compounds show moderate antimicrobial activity.

A NEW SYNTHESIS OF β-KETO AMIDES VIA REACTION OF KETONE LIZHIUM ENOLATES WITH ISOCYANATES

A series of β-ketoamides was prepared by a convenient new method involving addition of various isocyanates to lithium enolates of acetophenone propiophenone and pinacolone.