962-08-3

Usage

Uses

Used in Pharmaceutical Industry:
N-(4-chlorophenyl)-beta-oxo-benzenepropanamide is used as a key intermediate in the synthesis of various drugs. Its unique chemical structure allows it to be incorporated into a wide range of pharmaceutical compounds, contributing to the development of new and effective medications.
Used in Agrochemical Industry:
In the agrochemical industry, N-(4-chlorophenyl)-beta-oxo-benzenepropanamide is utilized as an intermediate for the production of various agrochemicals. Its involvement in the synthesis of these compounds helps to create effective solutions for agricultural applications, such as pest control and crop protection.
Used in Fragrance and Flavoring Industry:
N-(4-chlorophenyl)-beta-oxo-benzenepropanamide is also used in the synthesis of fragrances and flavorings. Its unique chemical properties make it a valuable component in creating a diverse range of scents and tastes for various consumer products.
Overall, N-(4-chlorophenyl)-beta-oxo-benzenepropanamide plays a significant role in the chemical industry due to its diverse applications across different sectors, including pharmaceuticals, agrochemicals, and the fragrance and flavoring industry. Its versatility as a chemical intermediate makes it an essential component in the development and production of various products.

Upstream product

• 13165-68-9 N-(4-chloro-phenyl)-sulfur imide oxide 
• 55991-67-8 5-phenylfuran-2,3-dione 
• 104-12-1 p-chlorphenylisocyanate 
• 98-86-2 acetophenone 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 106-47-8 4-chloro-aniline 
• 10507-69-4 4-methoxybenzohydroxamic acid 
• 132401-91-3 3-(4-chlorophenyl)-1,4,2-dioxazol-5-one 

Downstream Products

• 88078-12-0 (3aR,9aS)-3-Benzoyl-1-(4-chloro-phenyl)-4-methyl-1,3,3a,4,9,9a-hexahydro-pyrrolo[2,3-b]quinoxalin-2-one 
• 88078-13-1 (3aR,9aS)-3-Benzoyl-1-(4-chloro-phenyl)-4-ethyl-1,3,3a,4,9,9a-hexahydro-pyrrolo[2,3-b]quinoxalin-2-one 
• 126081-41-2 2-{2-[3-(4-Chloro-phenylamino)-5-phenyl-pyrazol-1-yl]-2-oxo-ethyl}-4-phenyl-2H-phthalazin-1-one 
• 98-86-2 acetophenone 
• 1219-99-4 N,N'-bis(4-chlorophenyl)urea 
• 128692-09-1 3-Benzoyl-1-(4-chloro-phenyl)-2,6-dihydroxy-1H-pyridin-4-one 

Relevant academic research and scientific papers

1,4,2-Dioxazol-5-ones as Isocyanate Equivalents: An Efficient Synthesis of 2-Quinolinones via β-Keto Amides

Under thermal conditions, 1,4,2-dioxazol-5-ones are known to undergo decarboxylation followed by Lossen's rearrangement to yield isocyanates. Described herein is the in situ trapping of the resulting isocyanates with carbon nucleophiles to synthesize β-keto amides. Furthermore, a general and mild method for the conversion of the resulting β-keto amides into quinolin-2-ones is reported.

Copper-Catalyzed Aerobic Oxidations of 3-N-Hydoxyaminoprop-1-ynes to Form 3-Substituted 3-Amino-2-en-1-ones: Oxidative Mannich Reactions with a Skeletal Rearrangement

Cu-catalyzed aerobic oxidations of readily available 3-N-hydroxyaminopro-1-ynes with water, alcohols, or thiols to form diverse 3-substituted 3-amino-2-en-1-ones are described. The utility of this catalysis is manifested by a wide scope of applicable N-hydroxyl propargylamines and nucleophiles, thus enabling the design of one-pot cascade or two-step sequential reactions. Besides synthetic significances, such oxidative Mannich reactions are mechanistically interesting because structurally reorganized products were obtained. Our mechanistic studies reveal that the aerobic oxidations involve initial formation of nitrone intermediates, followed by the attack of nucleophiles. Herein, water and MeOH implement the conversion of nitrone intermediates to reaction products in two distinct pathways. Go Mannich! Cu-catalyzed aerobic oxidations of 3-N-hydroxyaminopro-1-ynes with water, alcohols, or thiols to form diverse 3-substituted 3-amino-2-en-1-ones are reported (see scheme). Such oxidative Mannich reactions are mechanistically interesting, because structurally reorganized products were obtained.

A NEW SYNTHESIS OF β-KETO AMIDES VIA REACTION OF KETONE LIZHIUM ENOLATES WITH ISOCYANATES

A series of β-ketoamides was prepared by a convenient new method involving addition of various isocyanates to lithium enolates of acetophenone propiophenone and pinacolone.

OXIDATION OF ENAMINE-ESTERS WITH LEAD TETRA-ACETATE - PART 3. β-AMINOCINNAMATES AND β-AMINOCROTONATES

Oxidation of β-aminocinnamates and β-aminocrotonates with lead tetra-acetate gives fully substituted pyrrole-3,4-diesters.