96202-57-2Relevant articles and documents
Synthesis of substituted tryptanthrin via aryl halides and amines as antitumor and anti-MRSA agents
Chen, Huan,Hou, Baolong,Liu, Jianli,Liu, Li,Ma, Xiumei,Wang, Cuiling,Wang, Jilin,Wang, Rui,Wang, Yinyin,Zheng, Xudong
, (2019/11/13)
The natural alkaloid, tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), and its analogues are found to exhibit potent antitumor and anti-MRSA activities. An efficient and convenient method has been developed for the synthesis of tryptanthrin D-ring derivatives through the reaction of substituted tryptanthrins and secondary amines in moderate to good yields. Some of the new compounds exhibited antitumor activities against the human tumor cell lines A549, HCT116 and MDA-MB-231, with mean IC50 values at low micromolar levels. In addition, some of the compounds showed excellent anti-MRSA activities and were more effective than vancomycin, with MIC values of 0.31–1.25 μg/mL for Mu50,RN4220, and Newman strains.
TRPV4 ANTAGONISTS
-
Page/Page column 37, (2011/10/13)
The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as β-amyloid aggregation inhibitors
Campagna, Francesco,Catto, Marco,Purgatorio, Rosa,Altomare, Cosimo D.,Carotti, Angelo,De Stradis, Angelo,Palazzo, Gerardo
scheme or table, p. 275 - 284 (2011/02/27)
A series of isatin-3-arylhydrazones were synthesized and evaluated in vitro as inhibitors of Aβ1-40 aggregation using a thioflavin T fluorescence method. An exploration of the effects on Aβ1-40 aggregation of a number of diverse subs
