96206-94-9Relevant articles and documents
Methylenecyclopropane Ring Formation/Opening Cascade for the Synthesis of Indolizines
Zhu, Congjun,Zhao, Peng,Qiao, Yan,Xiao, Ke,Song, Chuanjun,Chang, Junbiao
, p. 7045 - 7049 (2017/07/15)
A unique strategy toward the synthesis of polysubstituted indolizines has been developed. When 2-pyridinyl-2-(2′-bromoallyl)-1-carboxylates were treated with Cs2CO3, the starting material went through a methylenecyclopropane ring formation/opening cascade, and the corresponding indolizines were obtained in moderate to good yield as a single regioisomer.
Synthesis of indolizine derivatives with selective antibacterial activity against Mycobacterium tuberculosis
Gundersen, Lise-Lotte,Charnock, Colin,Negussie, Ayele Hailu,Rise, Frode,Teklu, Solomon
, p. 26 - 35 (2007/10/03)
1-Substituted indolizines with activity against Mycobacterium tuberculosis have been synthesized. The most active compounds carry an hydroxyphenylmethyl- or hydroxyalkyl substituent in the indolizine 1-position. The alkyl chain should be moderately long (C-5 or C-6). Aryl groups in the 2- and 3-position of the indolizine are also required. Removal of the 3-substituent resulted in significant loss of activity. A nitrile substituent in the 7-position is beneficial for both chemical stability and bioactivity. The compounds studied display a narrow antibacterial spectrum and appear to be quite selective antimycobacterial compounds. Moderate activity against certain pathogenic protozoa was also observed.
Thermal Rearrangements of Cyclic Amine Ylides. VIII. Intramolecular Cyclization of 2-Ethynylpyridine N-Ylides into Indolizines and Cyclazines
Sashida, Haruki,Kato, Masanobu,Tsuchiya, Takashi
, p. 3826 - 3832 (2007/10/02)
Treatment of 6-unsubstituted 2-ethynyl-1-phenacylpyridinium bromides (10a-c) with 1,5-diazabicycloundec-5-ene in refluxing benzene resulted in cyclization to give the 3-benzoyl-indolizines (11) via the N-ylide intermediates 13, whereas heating the
