96221-91-9

Basic information

• Product Name: Benzoic acid, 2-[[(phenylamino)thioxomethyl]amino]-, methyl ester
• CAS NO: 96221-91-9
• Molecular Formula: C15H14N2O2S
• Molecular Weight: 286.354
• Mol File: 96221-91-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-[[(phenylamino)thioxomethyl]amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[[(phenylamino)thioxomethyl]amino]-, methyl ester(96221-91-9)
• EPA Substance Registry System: Benzoic acid, 2-[[(phenylamino)thioxomethyl]amino]-, methyl ester(96221-91-9)

Safety Data

• Hazardous Substances Data: 96221-91-9(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 18418-42-3 phenyl-dithiocarbamic acid; sodium salt 
• 103-72-0 phenyl isothiocyanate 
• 134-20-3 2-carbomethoxyaniline 
• 701-73-5 methyl N-phenyldithiocarbamate 

Downstream Products

• 18741-24-7 3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 67811-46-5 4-phenyl-5-oxo-4,5-dihydro-s-triazolo-<4,3-a>-quinazoline 
• 68357-48-2 1-methyl-4-phenyl-1,2,4-triazolo<4,3-a>quinazolin-5(4H)-one 
• 67629-33-8 4-phenyl-[1,2,4]triazolo[4,3-a]quinazoline-1,5(2H,4H)-dione 
• 67442-90-4 4-phenyl-5-oxo-1-thioxo-1,2,4,5-tetrahydro-s-triazolo<4,3-a>-quinazoline 
• 59342-38-0 4-phenyl-4,5-dihydrotetrazolo<1,2-a>-5-quinazolone 
• 121662-02-0 2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylquinazolin-4(3H)-one 
• 66679-85-4 2-(2-(4-chlorobenzylidene)hydrazinyl)-3-phenylquinazolin-4(3H)-one 
• 86842-51-5 2-(N'-4-methoxybenzylidenehydrazino)-3-phenyl-3H-quinazolin-4-one 
• 731-52-2 2-hydrazino-3-phenyl-3H-quinazolin-4-one 
• 3318-07-8 benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone 
• 73987-32-3 2-methylmercapto-3-phenyl-4(3H)-quinazolinone 
• 305850-37-7 2-(N'-4-nitrobenzylidenehydrazino)-3-phenyl-3H-quinazolin-4-one 

Relevant articles and documents

Anti-HIV and Antibacterial Activities of Novel 2-(3-Substituted-4-oxo-3,4-dihydroquinazolin-2-yl)-2,3-dihydrophthalazine-1,4-diones

Abstract: In the present study, we have synthesized a series of novel 2-(3-substituted-4-oxo-3,4-dihydroquinazolin-2-yl)-2,3-dihydrophthalazine-1,4-diones by the reaction of 3-(substituted)-2-hydrazino-quinazoline-4(3H)-ones with phthalic anhydride. The starting material 3-(substituted)-2-hydrazino-quinazolin-4(3H)-ones were synthesized from various primary amines. All the synthesized compounds were screened for their antitubercular, anti-HIV and antibacterial activity against different gram positive and gram negative strains by agar dilution method. Among the test compounds, 2-(3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-2,3-dihydrophthalazine-1,4-dione (QCT7) shown most potent antibacterial activity against E. coli, and S. aureus with the MIC of 3 μg/mL. The compound QCT7 exhibited the antitubercular activity with the MIC of 25 μg/mL and anti-HIV activity with the EC50 of 43.68 μM against HIV1 and HIV2 and offers potential lead for further optimization and development to new antitubercular and anti-HIV agents. The results obtained from this study confirm that the synthesized and biologically evaluated quinazolines showed promising antimicrobial, antitubercular and anti-HIV activities and are new scaffolds for antimicrobial activity.

Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents

A variety of novel 3-phenyl-2-substituted-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-phenyl-3H-quinazolin-4-one with different aldehydes and ketones. The starting material 2-hydrazino-3-phenyl-3H-quinazolin-4-one was synthesized from aniline. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. While the test compounds exhibited significant activity, compounds, 2-(N′-2-butylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS1), 2-(N′-3-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS2) and 2-(N′-2-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS3), exhibited moderate analgesic activity. The compound 2-(N′-2-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS3) showed more potent anti-inflammatory activity when compared to the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic side effect when compared to aspirin.

Synthesis of aryl thioureas and related compounds as potential fungicides

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