67442-90-4

Usage

Uses

Used in Pharmaceutical Industry:
[1,2,4]Triazolo[4,3-a]quinazolin-5(1H)-one, 2,4-dihydro-4-phenyl-1-thioxois used as a potential therapeutic agent for various diseases due to its pharmacological activities. Its unique structure and potential medicinal properties make it a promising candidate for the development of new drugs and therapies.
Used in Chemical Research and Development:
[1,2,4]Triazolo[4,3-a]quinazolin-5(1H)-one, 2,4-dihydro-4-phenyl-1-thioxois used as a compound of interest in the research and development of new chemical entities. Its structural features and potential applications in various industrial processes make it a valuable subject for further study and exploration.
Used in Drug Discovery and Development Processes:
[1,2,4]Triazolo[4,3-a]quinazolin-5(1H)-one, 2,4-dihydro-4-phenyl-1-thioxois used as a candidate in drug discovery and development processes. Its potential pharmacological activities and unique structure make it an interesting compound to investigate for the development of new drugs and therapies.

Upstream product

• 75-15-0 carbon disulfide 
• 731-52-2 2-hydrazino-3-phenyl-3H-quinazolin-4-one 
• 29745-27-5 3-phenyl-2-ethylsulfanyl-2,3-dihydroquinazolin-4(1H)-one 
• 118-92-3 anthranilic acid 
• 103-72-0 phenyl isothiocyanate 
• 18741-24-7 3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 18741-24-7 2-mercapto-3-phenyl-3H-quinazolin-4-one 
• 73987-32-3 2-methylmercapto-3-phenyl-4(3H)-quinazolinone 
• 727-62-8 2-chloro-3-phenylquinazoline-4-(3H)-one 
• 603-23-6 3-phenyl-2,4-(1H,3H)-quinazolinedione 
• 18418-42-3 phenyl-dithiocarbamic acid; sodium salt 
• 62-53-3 aniline 
• 96221-91-9 N-o-Carbomethoxyphenyl-N'-phenylthiourea 
• 701-73-5 methyl N-phenyldithiocarbamate 

Downstream Products

• 86842-60-6 1-ethoxycarbonylmethylthio-4-phenyl-1,2,4-triazolo<4,3-a>quinazolin-5(4H)-one 
• 569336-26-1 1-oxo-4-phenyl-N²-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one 
• 569336-36-3 4-phenyl-N²-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranosyl)-1-thioxo[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one 
• 569336-22-7 4-phenyl-N²-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl)-1-thioxo[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one 
• 76462-03-8 1-Benzylsulfanyl-4-phenyl-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one 

Relevant academic research and scientific papers

Synthesis, biological evaluation and molecular docking studies of novel quinazolinones as antitubercular and antimicrobial agents

In the present study, a series of novel quinazolinone hybrids, viz. triazepino-quinazolinones 4, thiazolo-triazolo-quinazolinones 7 and triazolo-quinazolinones 8 have been synthesized from the key intermediate 3-(substituted phenyl)-2-hydrazinoquinazolin-4(3H)-ones 3. All the newly synthesized compounds were characterized by means of spectral (IR, 1H NMR, 13C NMR) and elemental analysis. The target compounds were biologically screened for their in vitro antimicrobial and antitubercular activities against pathogenic strain. The results of bioassay demonstrated that some of the compounds exhibited pronounced antimicrobial activity comparable to that of standard drugs tested under similar conditions. Compounds 4c, 4e, 7e and 8b showed relatively very good inhibitory activity against pathogenic bacteria with minimum inhibitory concentration (MIC) of 2.6 μg/mL, 5.2 μg/mL, while the rest of the compounds showed moderate activity. Compounds 4c and 8b were found to be nearly equipotent with ciprofloxacin against P. aeruginosa with MIC 5.2 μg/mL, while compound 8b was more potent against pathogenic bacteria S. aureus. It is very remarkable that four compounds, 4c, 4e, 7e and 8b showed pronounced antifungal activity against selected pathogenic fungi, A. niger, C. albicans with MIC 2.6 μg/mL and 5.2 μg/mL. The antitubercular activity of synthesized compounds reveal that compound 8b showed better activity than the other compounds with a MIC of 5.2 μg/mL against M. tuberculosis (H37Rv). Molecular docking studies of the compounds were performed to rationalize the inhibitory properties of these compounds and results showed that these compounds have good binding energy and better binding affinity within the active pocket, thus these compounds may be considered as potent inhibitors towards selective targets.

Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one and Its Derivatives

A series of 4-(substituted-phenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-ones (6a-x) with triazole and other heterocyclic substituents (7-14) were synthesized and the compounds were evaluated for their anticonvulsant activity and neurotoxicity by maximal electroshock (MES) and rotarod neurotoxicity tests. Among the compounds studied, 6o and 6q showed wide margins of safety with protective indices (PIs) that were much higher than those of currently used drugs (PI6o > 25.5, PI6q > 26.0). Compounds 6o and 6q showed significant oral activity against MES-induced seizures in mice, with ED50 values of 88.02 and 94.6 mg/kg, respectively. The two compounds were also found to have potent activity against seizures that were induced by pentylenetetrazole and bicuculline. A series of 4-(substituted-phenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-ones with triazole and other heterocyclic substituents were synthesized and the compounds were evaluated for their anticonvulsant activity and neurotoxicity using maximal electroshock and rotarod neurotoxicity tests.

Spectral characterization of novel 3-phenyl-2-substituted quinazoline and fused quinazoline derivatives

3-phenyl-2-thioxo-quinazolin-4(3H)one 1 was utilized for the construction of some novel 2-substituted quinazolin-4(3H)one derivatives through the formation of 2-hydrazinyl quinazolinone, which was used as the key starting material for the synthesis of 2-heteryl quinazolines via the reaction with one carbon donors, -diketones and -ketoester. Infrared, 1H NMR, and mass spectra of the synthesized compounds were discussed. Some of them showed promising anti-inflammatory activity. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

Synthesis of the 1,2,4-Triazoloquinazolin-5-ones and Related Compounds

2-Hydrazino-3-phenyl-4(3H)-quinazolinone (1) underwent ring closure with aliphatic acid, aldehydes, and carbon disulfide to 1-alkyl-, 1-aryl-, and 1-mercapto-4-phenyl-1,2,4-triazoloquinazolin-5(4H)-ones (7) for instance.The 1-alkylthio-3-phenyl-1,2

Synthesis of Some Fused-ring Derivatives from 4(3H)-Quinazolone

A few more well-defined mesoionic thiazoloquinazolones have been synthesized and their properties recorded.Attempts to build-up analogous fused-ring mesoionic systems via 2-chloro-3-phenyl-4-quinazolone have not been successful.Several new triazolo