3318-07-8Relevant academic research and scientific papers
A new convenient synthesis of 2,4-disubstituted-1,2,4-triazolo[1,5-a] quinazolin-5(4H)-ones
Shawali, Ahmad S.,Hassaneen, Hamdi M.,Shurrab, Nabil Kh.
experimental part, p. 1825 - 1829 (2009/06/08)
(Chemical Equation Presented) A novel series of 2,4 disubstituted-1,2,4- triazolo[1,5-a]quinazolin-5(4H)-ones were prepared by Dimroth rearrangement of their respective isomers namely 1,4-disubstituted-[1,2,4]triazolo[4,3-a]- quinazolin-5(4H)-ones. The la
Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents
Alagarsamy,Raja Solomon,Dhanabal
, p. 235 - 241 (2008/02/02)
A variety of novel 3-phenyl-2-substituted-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-phenyl-3H-quinazolin-4-one with different aldehydes and ketones. The starting material 2-hydrazino-3-phenyl-3H-quinazolin-4-one was synthesized from aniline. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. While the test compounds exhibited significant activity, compounds, 2-(N′-2-butylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS1), 2-(N′-3-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS2) and 2-(N′-2-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS3), exhibited moderate analgesic activity. The compound 2-(N′-2-pentylidene-hydrazino)-3-phenyl-3H-quinazolin-4-one (AS3) showed more potent anti-inflammatory activity when compared to the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic side effect when compared to aspirin.
Chemistry of Quinazolines: Reinvestigation of the Action of Hydrazine on Thioxo Derivatives
Badawy, Mohamed A.,Abdel-Hady, Sayed A. L.,Ibrahim, Yehia A.,Kadry, Azza M.
, p. 1535 - 1536 (2007/10/02)
The action of hydrazine on 2-mercapto and 2-alkylmercaptoquinazolin-4-ones is reinvestigated.The structure of the isolated products have been revised.
