96334-44-0Relevant academic research and scientific papers
Discovery of new thiophene, pyrazole, isoxazole derivatives as antitumor, c-Met, tyrosine kinase and Pim-1 kinase inhibitors
Mohareb, Rafat Milad,Hilmy, Khalid M. H.,Elshehawy, Yasser Abdelaziz
, p. 285 - 308 (2018/09/06)
The reaction of cyclohexan-1,3-dione (1) with ethyl orthoformate (2) in acetic acid gave the 2-(ethoxymethylene)cyclohexane-1,3-dione (3). The latter compound was used for further heterocyclization reactions to give thiophene, pyrazole and pyran derivativ
The reaction of cyclohexan-1,3-dione with cyanomethylenes: Synthesis of thiophenes and their fused derivatives with antifungal activities
Mohareb, Rafat M.,Sherif, Sherif M.,Moustafa, Hosam El-Dean
experimental part, p. 2078 - 2096 (2010/02/28)
2-Amino-7-oxotetrahydrobenzo[b]thiophenes 3a,b were prepared according to the Gewald procedure. Their reactivity toward a variety of chemical reagents was studied to give annulated heterocycles with potential bio-responses.
Heterocyclic compound having oxime group
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, (2010/02/14)
The present invention provides a compound that has an excellent inhibitory activity on STAT6 activation and is effective against allergic diseases, and a medicinal composition thereof. According to the present invention, disclosed is the compound represented by the General Formula (I) [where R1 and R2 independently represent a C1-6 alkyl group and the like that may have a hydrogen atom or a substituent; R3 represents a C1-6 alkyl group and the like that may have a substituent; R4 and R5 independent represents a hydrogen atom or a C1-6 alkyl group and the like that may have a substituent; R6 represents a hydrogen atom and the like; W represents —SO2— and the like; and X represents a sulphur atom and the like.]or a salt thereof, or a hydrate thereof.
SYNTHESIS AND STRUCTURE OF DERIVATIVES OF 7-OXO-4,5,6,7-TETRAHYDROBENZOTHIOPHENE AND 7-HYDROXYBENZOTHIOPHENE
Kharizomenova, I. A.,Kapustina, M. V.,Grinev, A. N.,Sheinker, Yu. N.,Alekseeva, L. M.,Kuleshova, E. F.
, p. 1339 - 1342 (2007/10/02)
The oxidation of 2-acylamino-3-ethoxycarbonyl-4,5,6,7-tetrahydrobenzothiophenes gave the corresponding 7-oxotetrahydrobenzothiophenes and some of the transformations of these compounds were studied.These compounds were used for the synthesis of 3-et
