96530-75-5

Usage

Uses

Used in Pharmaceutical Industry:
2-HYDROXY-4-FLUOROPYRIDINE is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs. Its unique structure allows for specific reactivity and functional group manipulation, which is crucial in medicinal chemistry for creating novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 2-HYDROXY-4-FLUOROPYRIDINE serves as an intermediate in the production of pesticides and other agricultural chemicals. Its incorporation can enhance the effectiveness of these products, potentially leading to improved crop protection and yield.
Used in Specialty Chemicals Industry:
2-HYDROXY-4-FLUOROPYRIDINE is utilized as a building block in the synthesis of specialty chemicals, which are high-value compounds used in various applications such as coatings, adhesives, and sealants. Its unique combination of a hydroxyl and fluorine atom provides specific properties that can be tailored for these applications.
Used in Industrial Chemistry:
2-HYDROXY-4-FLUOROPYRIDINE plays a role in the broader field of industrial chemistry, where it is employed in the synthesis of materials with specific properties required for various industrial applications. Its versatility and reactivity make it a valuable component in the development of new materials and processes.

InChI:InChI=1/C5H4FNO/c6-4-1-2-7-5(8)3-4/h1-3H,(H,7,8)

Upstream product

• 96530-81-3 4-fluoro-2-methoxypyridine 
• 34941-90-7 2,4-difluoropyridine 
• 141-52-6 sodium ethanolate 
• 38767-72-5 3-deazaC 
• 14432-12-3 4-Amino-2-chloropyridine 
• 14395-39-2 2-methoxy-4-nitropyridine N-oxide 
• 20265-39-8 4-amino-2-methoxypyridine 

Downstream Products

• 1263184-56-0 C₁₇H₁₇FN₂O₂ 
• 1263184-41-3 C₁₈H₁₉FN₂O₂ 

Relevant academic research and scientific papers

One-step hydroxylation of aryl and heteroaryl fluorides using mechanochemistry

Simple use of KOH allows the direct F to OH exchange of aromatic and heteroaromatic substrates under mechanochemical conditions. The reaction is performed in the absence of solvent with potassium hydroxide as OH source. As a result, this approach is both more atom economical and environmentally friendly than previously described methods for this transformation.

Concise Entries to 4-Halo-2-pyridones and 3-Bromo-4-halo-2-pyridones

Methods for the synthesis of both simple 4-halo-2-pyridones and more functionalized 3,4-di- and (3,4,5-tri)-halo-2-pyridones are described that are based on a combination of Sandmeyer and regioselective (copper-mediated) halogenation, with a 2-chloro or a 2-benzyloxy moiety serving as a masked 2-pyridone.

Ortho-selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with anionic nucleophiles

The nucleophilic addition of organic anions to aromatic compounds with halogens positioned both ortho and para to activating groups was studied in a variety of solvents. Substrates showed strong preferences for ortho substitution in most cases. Evidence is presented for activating group-dependent coordination, which contributes to very high ortho-selectivity in nonpolar solvents. This also drives the overall reaction rate in these solvents, and is of close to the same magnitude of rate increase derived from polar solvents. para-Products are maximized by using crown ethers in protic solvents. Solvent effects overall are very different from corresponding reactions with amine nucleophiles due primarily to the different charges present in the transition states, and to solvation of the nucleophile.

Lactam enolate-pyridone addition: Synthesis of 4-halocytisines

The application of a lactam enolate-pyridone addition sequence, originally developed for cytisine, has been applied successfully to generate the first examples of 4-halocytisines. Variation of the lactam component provides cyfusine and 4-fluorocyfusine.