96800-65-6

Upstream product

• 139225-43-7 <3-(4-acetylphenyl)-2-oxo-5-oxazolidinyl>methyl methanesulfonate 
• 73018-98-1 3-azidopropane-1,2-diol 
• 49647-20-3 4-acetylphenyl isocyanate 
• 64590-46-1 3-(4-acetylphenyl)-2-oxo-5-(hydroxymethyl)oxazolidinone 
• 99-92-3 p-aminobenzophenone 
• 64590-54-1 3-<(4-acetylphenyl)amino>-1,2-propanediol 
• 367925-74-4 5-azidomethyl-3-phenyl-1,3-oxazolidin-2-one 
• 1071789-18-8 3-(4-acetylphenyl)-5-(bromomethyl)-oxazolidin-2-one 

Downstream Products

• 96800-71-4 5-(aminomethyl)-3-(4-acetylphenyl)-2-oxooxazolidine 
• 1071789-09-7 3-(4-acetylphenyl)-5-((4-octyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one 
• 1071789-11-1 3-(4-acetylphenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one 
• 1071789-10-0 3-(4-acetylphenyl)-5-((4-(2-hydroxyethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one 
• 1071789-12-2 3-(4-acetylphenyl)-5-((4-(trimethylsilyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis of triazole-oxazolidinones via a one-pot reaction and evaluation of their antimicrobial activity

C-5-substituted triazole-oxazolidinones were synthesized using a bromide catalyzed cycloaddition between aryl isocyanates and epibromohydrin followed by a three-component Huisgen cycloaddition. The library of compounds was screened for antibacterial activity against Mycobacterium smegmatis ATCC 14468, Bacillus subtilis ATCC 6633, and Enterococcus faecalis ATCC 29212. Notably, the 3-(4-acetyl-phenyl)-5-(1H-1,2,3-triazol-1-yl)methyl)-oxazolidin-2-one (18) showed an MIC of 1 μg/mL against M. smegmatis ATCC 14468, fourfold lower than the MIC measured for isoniazid.

Synthesis of oxazolidinones by a solid-phase/activation cycloelimination (sp/ace) methodology

A versatile method for the solid-phase synthesis of oxazolidinones is described. An appropriate 1,2-diol is attached to immobilized sulfonyl chloride, resulting in the selective activation of one of the alcohol functions. The subsequent reaction of the ot

Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 1. The 'B' group

The synthesis and structure/activity studies of the effect of varying the 'B' group in a series of oxazolidinone antibacterials (I) are described. Two synthetic routes were used: (1) alkylation of aniline with glycidol followed by dialkyl carbonate heterocyclization to afford I (A = H, B = OH), whose arene ring was further elaborated by using electrophilic aromatic substitution methodology; (2) cycloaddition of substituted aryl isocyanates with epoxides to give A and B with a variety of values. I with B = OH or Br were converted to other 'B' functionalities by using S(N)2 methodology. Antibacterial evaluation of compounds I with A = acetyl, isopropyl, methylthio, methylsulfinyl, methylsulfonyl, and sulfonamido and a variety of different 'B' groups against Staphylococcus aureus and Enterococcus faecalis concluded that the compounds with B = aminoacyl, and particularly acetamido, were the most active of those examined in each A series, possessing MICs in the range of 0.5-4 μg/mL for the most active compounds described.

Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents

Novel aminomethyl oxooxazolidinyl benzene derivatives, including the sulfides, sulfoxides, sulfones and sulfonamides, such as (l)-N-[3-[4-(methylsulfinyl)phenyl]-2-oxooxazolidin-5-ylmethyl]acetamide, possess useful antibacterial activity.