97267-61-3

Usage

Uses

Used in Organic Chemistry Synthesis:
7-Bromo-4-chloro-1,5-naphthalenedicarboxaldehyde is used as a reagent in the synthesis of organic compounds, facilitating various chemical reactions due to its reactive nature and strong oxidizing properties.
Used in Dye Production:
7-BroMo-4-chloro-1,5-naph... is utilized as a key intermediate in the production of dyes, contributing to the development of colorants for different applications.
Used in Pharmaceutical Manufacturing:
7-Bromo-4-chloro-1,5-naphthalenedicarboxaldehyde is employed in the manufacturing process of pharmaceuticals, playing a crucial role in the synthesis of certain medicinal compounds.
Used in the Production of Other Organic Substances:
Beyond dyes and pharmaceuticals, this chemical compound is also used in the production of a range of other organic substances, highlighting its broad applicability in the chemical industry.

Upstream product

• 1151802-13-9 5-{[(5-bromopyridin-3-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 64436-94-8 diethyl 2-(((5-bromopyridin-3-yl)amino)methylene)malonate 
• 66093-18-3 ethyl 7-bromo-4-oxo-1,4-dihydro-1,5-naphthyridine-3 -carboxylate 
• 13535-01-8 3-amino-5-bromopyridine 
• 39620-02-5 5-bromonicotinoyl chloride 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 28733-43-9 5-bromonicotinamide 
• 17965-71-8 3-bromo-1,5-naphthyridine 
• 56247-24-6 3-bromo-1,5-naphthyridine-5-oxide 
• 64436-97-1 ethyl 7-bromo-4-hydroxy-1,5-naphthyridine-3-carboxylate 
• 97267-59-9 7-bromo-4-hydroxy-1,5-naphthyridine-3-carboxylic acid 
• 97267-60-2 7-bromo-1,5-naphthyridin-4-ol 

Downstream Products

• 130806-55-2 5-(7''-bromo-1'',5''-naphthyridin-4''-ylamino)-3-(t-butylaminomethyl)-4'-chlorobiphenyl-2-ol 
• 130806-54-1 5-(7''-bromo-1'',5''-naphthyridin-4''-ylamino)-4'-chloro-3-diethylaminomethylbiphenyl-2-ol 
• 130806-56-3 5-(7''-bromo-1'',5''-naphthyridin-4''-ylamino)-4'-chloro-3-(piperidin-1'''-ylmethyl)biphenyl-2-ol 
• 130806-57-4 5-(7''-bromo-1'',5''-naphthyridin-4''-ylamino)-4'-chloro-3-(3'''-methylpiperidin-1'''-ylmethyl)biphenyl-2-ol 
• 130806-58-5 5-(7''-bromo-1'',5''-naphthyridin-4''-ylamino)-4'-chloro-3-(4'''-methylpiperidin-1'''-ylmethyl)biphenyl-2-ol 
• 130806-60-9 3-(4''-benzylpiperazin-1''-ylmethyl)-5-(7'''-bromo-1''',5'''-naphthyridin-1'''-ylamino)-4'-chlorobiphenyl-2-ol 
• 97267-43-1 4-(7'-bromo-1',5'-naphthyridin-4'-ylamino)-2-(diethylaminomethyl)phenol 
• 100422-45-5 4-(7'-bromo-1',5'-naphthyridin-4'-ylamino)phenol 
• 97267-50-0 4-('-bromo-1',5'-naphthyridin-4'-ylamino)aniline 
• 97267-51-1 N,N'-bis(7'-bromo-1'',5''-naphthyridin-4''-yl)benzene-1,4-diamine hydrochloride 
• 133394-04-4 4-(7'-bromo-1',5'-naphthyridin-4'-ylamino)-2,6-bis(dimethylaminomethyl)-3-methylphenol 
• 133394-20-4 4-(7'-bromo-1',5'-naphtyridin-4'-ylamino)-2,6-bis(t-butylaminomethyl)-3-methylphenol 
• 133394-19-1 4-(7'-bromo-1',5'-naphthyridin-4'-ylamino)-2,6-bis(diethylaminomethyl)-3-methylphenol 
• 133394-21-5 4-(7'-bromo-1',5'-naphthyridin-4'-ylamino)-3-methyl-2,6-bis(pyrrolidin-1''-ylmethyl)phenol 

Relevant academic research and scientific papers

HETEROCYCLIC NLRP3 MODULATORS, FOR USE IN THE TREATMENT OF CANCER

The present invention provides compounds of Formula (I): wherein all of the variables are as defined herein. These compounds are modulators of NLRP3, which may be used as medicaments for the treatment of proliferative disorders, such as cancer in a subjec

Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells

A novel series of (7-aryl-1,5-naphthyridin-2-yl)ureas was discovered as dual ERK2 and Aurora B kinases inhibitors. Several analogues were active at micromolar and submicromolar range against ERK2 and Aurora B, associated with very promising antiproliferat

Discovery of 7-aryl-substituted (1,5-naphthyridin-4-yl)ureas as Aurora kinase inhibitors

As part of our research projects to identify new chemical entities of biological interest, we developed a synthetic approach and the biological evaluation of (7-aryl-1,5-naphthyridin-4-yl)ureas as a novel class of Aurora kinase inhibitors for the treatment of malignant diseases based on pathological cell proliferation. 1,5-Naphthyridine derivatives showed excellent inhibitory activities toward Aurora kinases A and B, and the most active compound, 1-cyclopropyl-3-[7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridin-4-yl]urea (49), displayed IC50 values of 13 and 107 nM against Aurora kinases A and B, respectively. In addition, the selectivity toward a panel of seven cancer-related protein kinases was highlighted. In vitro ADME properties were also determined in order to rationalize the difficulties in correlating antiproliferative activity with Aurora kinase inhibition. Finally, the good safety profile of these compounds imparts promising potential for their further development as anticancer agents. Promising Aurora inhibitors: Herein we report a series of (7-aryl-1,5-naphthyridin-4-yl)ureas as a novel class of nanomolar-range Aurora kinase inhibitors. The described derivatives have good cell-penetration parameters and safety profiles, but their efficiency toward signaling pathways are insufficient to induce cell death. We also highlight their selectivity toward a panel of seven cancer-related protein kinases. Copyright

Aurora Kinase Modulators and Method of Use

The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

NOVEL NAPHTHYRIDINE DERIVATIVES AND THE USE THEREOF AS KINASE INHIBITORS

The present invention relates to kinase modulators of the naphthyridine type and to the preparation and use thereof as medicaments for the modulation of misdirected cellular signal transduction processes, in particular for influencing the function of tyro

Novel Naphthyridine derivatives and the use thereof as kinase inhibitors

The present invention relates to kinase modulators of the naphthyridine type and to the preparation and use thereof as medicaments for the modulation of misdirected cellular signal transduction processes, in particular for influencing the function of tyro

AURORA KINASE MODULATORS AND METHOD OF USE

The present invention relates to chemical compounds having a general formula I {INSERT STRUCTURE HERE} wherein A1-8, D,, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.