97308-39-9

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 97308-38-8 3-bromo-4,6-dimethylpyridine 1-oxide 
• 27063-92-9 5-bromo-2,4-dimethyl-pyridine 
• 1193-71-1 5-amino-2,4-dimethylpyridine 

Downstream Products

• 97308-41-3 4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide 
• 97308-42-4 2,4-dimethyl-6-phenyl-1,7-naphthyridin-8(7H)-one 
• 97308-40-2 4,6-dimethyl-3-phenylethynyl-2-pyridinecarbonitrile 

Relevant academic research and scientific papers

SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted imidazo[1,2-b]pyridazine compounds, substituted imidazo[1,5-b]pyridazine compounds, related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,2-b]pyridazine compounds described herein include substituted imidazo[1,2-b]pyridazine-3-carboxamide compounds and variants thereof.

Condensed Heteroaromatic Ring Systems. III. Synthesis of Naphthyridine Derivatives by Cyclization of Ethynylpyridinecarboxamides

Four kinds of naphthyridinones, i.e. 1,6-naphthyridin-5-one, 1,7-naphthyridin-8-one, 2,6-naphthyridin-2-one, and 2,7-naphthyridin-1-one derivatives, were commonly synthesized by the intramolecular cyclization of pyridinecarboxamides having an ethynyl group or β,β-dimethoxyethyl group adjacent to the carbamoyl group.The syntheses of the starting pyridine derivatives were easily accomplished by cross-coupling of the corresponding halopyridines with acetylenes.Keywords-intramolecular cyclization; palladium catalyst; trimethylsilylacetylene; naphthyridinone; pyridineacetaldehyde; 1(2H)-isoquinolone