1193-71-1

Basic information

• Product Name: 3-Amino-4,6-dimethylpyridine
• Synonyms: 5-AMINO-2,4-DIMETHYLPYRIDINE;3-AMINO-4,6-DIMETHYLPYRIDINE;IFLAB-BB F1957-0017;3-Amino-4,6-dimethylpyridine 97%;4,6-dimethyl-3-pyridinamine;3-Amino-4,6-dimethylpyridine ,98%;5-Methyl-1H-pyrrole-3-carboxylic acid ethyl ester;3-PyridinaMine, 4,6-diMethyl-
• CAS NO: 1193-71-1
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• Product Categories: Heterocycles;Heterocyclic Compound;Pyridine series;Amines;Pyridines
• Mol File: 1193-71-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 68 °C
• Boiling Point: 257.11 °C at 760 mmHg
• Flash Point: 133.051 °C
• Appearance: /
• Density: 1.04 g/cm³
• Vapor Pressure: 0.0148mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.54±0.18(Predicted)
• CAS DataBase Reference: 3-Amino-4,6-dimethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4,6-dimethylpyridine(1193-71-1)
• EPA Substance Registry System: 3-Amino-4,6-dimethylpyridine(1193-71-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1193-71-1(Hazardous Substances Data)

Usage

General Description

3-Amino-4,6-dimethylpyridine, also known as 3-Amino-4,6-lutidine, is a chemical compound with the molecular formula C7H10N2. It is a heterocyclic aromatic amine with a pyridine ring substituted with an amino group at the 3 position and methyl groups at the 4 and 6 positions. 3-Amino-4,6-dimethylpyridine is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and dyes. It can also be used as a ligand in coordination chemistry and as a catalyst in organic reactions. Additionally, 3-Amino-4,6-dimethylpyridine has been investigated for potential applications in the field of organic electronics and as a corrosion inhibitor for metals. It is important to handle this chemical with care due to its potential health and environmental hazards.

InChI:InChI=1/C7H10N2/c1-5-3-6(2)9-4-7(5)8/h3-4H,8H2,1-2H3

Upstream product

• 1074-99-3 2,4-dimethyl-5-nitropyridine 
• 1074-76-6 2,4-dimethyl-3-nitropyridine 
• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 108-47-4 2,4-lutidine 

Downstream Products

• 76005-97-5 5-acetamido-2,4-dimethylpyridine 
• 27063-92-9 5-bromo-2,4-dimethyl-pyridine 
• 104829-98-3 3-amino-2-bromo-4,6-dimethylpyridine 
• 213685-57-5 2-amino-3-hydroxy-4,6-dimethylpyridine 
• 1346123-74-7 1-(4,6-dimethylpyridin-3-yl)-4-(toluene-4-sulfonyl)piperazine 
• 1417332-51-4 1-(4-Methoxy-phenyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (4,6-dimethyl-pyridin-3-yl)-amide 
• 76006-01-4 1-acetyl-5-methyl-1H-pyrazolo<3,4-c>pyridine 
• 76006-06-9 5-methyl-1H-pyrazolo[3,4-c]pyridine 
• 104830-09-3 2-bromo-3-iodo-4,6-dimethylpyridine 
• 97308-41-3 4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide 
• 97308-42-4 2,4-dimethyl-6-phenyl-1,7-naphthyridin-8(7H)-one 
• 97308-40-2 4,6-dimethyl-3-phenylethynyl-2-pyridinecarbonitrile 
• 97308-39-9 3-bromo-4,6-dimethyl-2-pyridinecarbonitrile 
• 143509-34-6 2,4-dimethyl-5-hydroxypyridine N-oxide 

Relevant articles and documents

FACTOR XI ACTIVATION INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY2or N; d is CY3or N; e is CY4or N; f is CY5or N; g is CY6or N; Y4, Y5, and Y6are independently hydrogen, C1-4alkyl, or halogen; Y1and Y2are independently hydrogen, C1-4alkyl, C3-7cycloalkyl, halogen, NH2, OH or C1-4alkoxy, and Y3is hydrogen, C1-4alkyl, C3-7cycloalkyl, halogen, —CN, NH2, OH or C1-4alkoxy; A is and W, W1, R1, R3, R4, R5, X and Z are defined in the specification.

Synthesis and Antitumor Activity of 3- and 5-Hydroxy-4-methylpyridibe-2-carboxaldehyde Thiosemicarbazones

To develop an α-(N)-heterocyclic carboxaldehyde thiosemicarbazone with clinical utility as an anticancer agent, two analogues, 3-hydroxy-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-HMP) and 5-hydroxy-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (5-HMP), of 5-hydroxypyridine-2-carboxaldehyde thiosemicarbazone (5-HP) have been designed and synthesized by two different methods. 3-HMP and 5-HMP both showed better antitumor activity than their respective parent compounds, 3-hydroxypyridine-2-carboxaldehyde thiosemicarbazone and 5-HP, in mice bearing the L1210 leukemia.