27063-92-9

Basic information

• Product Name: 5-BROMO-2,4-DIMETHYLPYRIDINE
• Synonyms: 5-BROMO-2,4-DIMETHYLPYRIDINE;PYRIDINE, 5-BROMO-2,4-DIMETHYL-
• CAS NO: 27063-92-9
• Molecular Formula: C₇H₈BrN
• Molecular Weight: 186.0491
• Product Categories: Heterocycle-Pyridine series
• Mol File: 27063-92-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 211.719 °C at 760 mmHg
• Flash Point: 81.845 °C
• Appearance: /
• Density: 1.416 g/cm³
• Vapor Pressure: 0.261mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.25±0.18(Predicted)
• CAS DataBase Reference: 5-BROMO-2,4-DIMETHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2,4-DIMETHYLPYRIDINE(27063-92-9)
• EPA Substance Registry System: 5-BROMO-2,4-DIMETHYLPYRIDINE(27063-92-9)

Safety Data

• Hazardous Substances Data: 27063-92-9(Hazardous Substances Data)

Usage

General Description

5-Bromo-2,4-dimethylpyridine is a chemical compound with the molecular formula C7H8BrN. It is a halogenated pyridine derivative that is commonly used as a building block in organic synthesis and pharmaceutical research. This chemical is often used as an intermediate in the production of various pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a valuable tool for the development of new compounds and materials. It is important to handle this compound with caution, as it may present health hazards if not used properly.

InChI:InChI=1/C7H8BrN/c1-5-3-6(2)9-4-7(5)8/h3-4H,1-2H3

Upstream product

• 108-47-4 2,4-lutidine 
• 1074-99-3 2,4-dimethyl-5-nitropyridine 
• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 1193-71-1 5-amino-2,4-dimethylpyridine 
• 3430-26-0 2,5-Dibromo-4-methylpyridine 
• 75-16-1 methylmagnesium bromide 
• 29976-20-3 3,5-dibromo-2,4-dimethylpyridine 
• 27063-93-0 3-bromo-2,4-dimethyl-pyridine 

Downstream Products

• 1001907-68-1 (4,6-dimethylpyridin-3-yl)boronic acid 
• 97308-41-3 4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide 
• 97308-42-4 2,4-dimethyl-6-phenyl-1,7-naphthyridin-8(7H)-one 
• 97308-40-2 4,6-dimethyl-3-phenylethynyl-2-pyridinecarbonitrile 
• 97308-39-9 3-bromo-4,6-dimethyl-2-pyridinecarbonitrile 

Relevant articles and documents

FACTOR XI ACTIVATION INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates

Based on structural analysis of the human 2-oxoglutarate (2OG) dependent JMJD2 histone Nε-methyl lysyl demethylase family, 3-substituted pyridine 2,4-dicarboxylic acids were identified as potential inhibitors with possible selectivity over other human 2OG oxygenases. Microwave-assisted palladium-catalysed cross coupling methodology was developed to install a diverse set of substituents on the sterically demanding C-3 position of a pyridine 2,4-dicarboxylate scaffold. The subsequently prepared di-acids were tested for in vitro inhibition of the histone demethylase JMJD2E and another human 2OG oxygenase, prolyl-hydroxylase domain isoform 2 (PHD2, EGLN1). A subset of substitution patterns yielded inhibitors with selectivity for JMJD2E over PHD2, demonstrating that structure-based inhibitor design can enable selective inhibition of histone demethylases over related human 2OG oxygenases.

Substituted pyridine-2,4-dicarboxylic acid derivatives and medicaments based on these compounds

The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I STR1 in which R1 and R2 have the meanings given. The invention also relates to a process for the preparation of the abovementioned compo